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CFTR antibody (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7)) (AA 1339-1351)

Details for Product anti-CFTR Antibody No. ABIN965878, Supplier: Log in to see
Antigen
  • CFTR
  • AW495489
  • Abcc7
  • RGD1561193
  • ABC35
  • ABCC7
  • CF
  • CFTR/MRP
  • MRP7
  • TNR-CFTR
  • dJ760C5.1
  • abc35
  • abcc7
  • cftr/mrp
  • mrp7
  • tnr-cftr
  • xcftr
  • cystic fibrosis transmembrane conductance regulator
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
  • cystic fibrosis transmembrane conductance regulator homolog
  • cftr-A
  • CFTR
  • Cftr
  • cftr
Epitope
AA 1339-1351
12
6
6
5
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Sheep (Ovine)
218
77
30
7
3
3
2
2
2
2
1
Host
Rabbit
142
65
12
Clonality
Polyclonal
Conjugate
This CFTR antibody is un-conjugated
8
8
7
7
7
7
7
7
7
7
7
7
7
7
1
1
1
Application
Immunohistochemistry (IHC)
153
141
134
115
35
28
27
8
3
2
2
2
2
1
1
Options
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to residues 1339-1351 of human CFTR (Cystic fibrosis transmembrane conductance regulator)
Alternative Name CFTR (CFTR Antibody Abstract)
Background CFTR (Cystic fibrosis transmembrane conductance regulator) is involved in the transport of chloride ions and binds SLC9A3R1. CFTR is an integral membrane protein. Defects in CFTR are the cause of cystic fibrosis (CF) , also known as mucoviscidosis. It belongs to the ABC transporter family and MRP subfamily.
Restrictions For Research Use only
Storage -20 °C
Background publications Karthikeyan, Leung, Ladias: "Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator." in: The Journal of biological chemistry, Vol. 276, Issue 23, pp. 19683-6, 2001 (PubMed).

Hoedemaeker, Davidson, Rose: "A model for the nucleotide-binding domains of ABC transporters based on the large domain of aspartate aminotransferase." in: Proteins, Vol. 30, Issue 3, pp. 275-86, 1998 (PubMed).

Neville, Rozanas, Price, Gruis, Verkman, Townsend: "Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry." in: Protein science : a publication of the Protein Society, Vol. 6, Issue 11, pp. 2436-45, 1998 (PubMed).

Tsui: "Mutations and sequence variations detected in the cystic fibrosis transmembrane conductance regulator (CFTR) gene: a report from the Cystic Fibrosis Genetic Analysis Consortium." in: Human mutation, Vol. 1, Issue 3, pp. 197-203, 1993 (PubMed).

Picciotto, Cohn, Bertuzzi, Greengard, Nairn: "Phosphorylation of the cystic fibrosis transmembrane conductance regulator." in: The Journal of biological chemistry, Vol. 267, Issue 18, pp. 12742-52, 1992 (PubMed).

Zielenski, Rozmahel, Bozon, Kerem, Grzelczak, Riordan, Rommens, Tsui: "Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene." in: Genomics, Vol. 10, Issue 1, pp. 214-28, 1991 (PubMed).

Cutting, Kasch, Rosenstein, Zielenski, Tsui, Antonarakis, Kazazian: "A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein." in: Nature, Vol. 346, Issue 6282, pp. 366-9, 1990 (PubMed).

Riordan, Rommens, Kerem, Alon, Rozmahel, Grzelczak, Zielenski, Lok, Plavsic, Chou: "Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA." in: Science (New York, N.Y.), Vol. 245, Issue 4922, pp. 1066-73, 1989 (PubMed).