Checkpoint Kinase 1 (CHEK1) (Middle Region) antibody

Details for Product No. ABIN965881
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Antigen
Synonyms An08g10320, AO090003000441, CHK1, chk1, C85740, Chk1, rad27, id:ibd2720, zgc:56093, CHEK1
Epitope
Middle Region
(47), (42), (31), (31), (20), (14), (11), (9), (9), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(386), (133), (125), (36), (26), (26), (14), (4), (3), (2), (2), (2), (1)
Host
Rabbit
(338), (39), (12), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4)
Application
ELISA, Western Blotting (WB)
(302), (157), (97), (56), (50), (47), (23), (19), (11), (4), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN965881
288.75 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to Middle residues of human CHEK1 (Serine/threonine-protein kinase Chk1)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name CHEK1(Serine/threonine-protein kinase Chk1)
Background The CHEK1 (Serine/threonine-protein kinase Chk1) is involved in cell cycle arrest when DNA damage has occurred or when unligated DNA is present. It binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25C creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2cyclin B complex and prevents mitotic entry. The CHEK1 phosphorylates CDC25C on serine-216.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Sanchez, Wong, Thoma et al.: "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25." in: Science (New York, N.Y.), Vol. 277, Issue 5331, pp. 1497-501, 1997 (PubMed).

Flaggs, Plug, Dunks et al.: "Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes." in: Current biology : CB, Vol. 7, Issue 12, pp. 977-86, 1998 (PubMed).

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