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Details for Product No. ABIN965889

Checkpoint Kinase 2 (CHEK2) (pSer516) antibody

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Antigen
Synonyms CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, Cds1, Rad53, HUCDS1, Chk2, CHK-2
Epitope
»Alternatives pSer516
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN965889
Quantity 100 µg
Price
385.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Chk2 around the phosphorylation site of serine 516 (Q-P-SP-T-S).
Specificity Chk2 (phospho-Ser516) antibody detects endogenous levels of Chk2 only when phosphorylated at serine 516.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Chk2
Research Area Cancer, Cell Cycle, DNA/RNA, Kinases/Phosphatases
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Storage -20 °C
Product cited in: Lou, Minter-Dykhouse, Wu et al.: "MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways." in: Nature, Vol. 421, Issue 6926, pp. 957-61, 2003 (PubMed).

Schwarz, Lovly, Piwnica-Worms: "Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation." in: Molecular cancer research : MCR, Vol. 1, Issue 8, pp. 598-609, 2003 (PubMed).

Wu, Chen: "Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36163-8, 2003 (PubMed).

Alternatives for antigen "Checkpoint Kinase 2 (CHEK2)", type "Antibodies"
Hosts (258), (70), (1)
Reactivities (319), (144), (143), (55), (37), (36), (12), (4), (3), (1), (1)
Applications (244), (115), (75), (66), (60), (34), (26), (19), (8), (3), (3), (2)
Conjugates (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1)
Epitopes (36), (32), (25), (24), (19), (13), (11), (8), (7), (6), (5), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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