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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Checkpoint Kinase 2 (CHEK2) (pSer516) antibody
|Synonyms||CDS1, CHK2, LFS2, RAD53, HuCds1, PP1425|
Alternatives Immunohistochemistry (IHC)
|3 references available|
|Quantity||100ug (100ug/100ul.) (Variants)|
|Price||385.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||The antiserum was produced against synthesized phosphopeptide derived from human Chk2 around the phosphorylation site of serine 516 (Q-P-SP-T-S).|
|Specificity||Chk2 (phospho-Ser516) antibody detects endogenous levels of Chk2 only when phosphorylated at serine 516.|
|Application Notes||WB: 1:500~1:1000.|
|Purification||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.|
|Buffer||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol|
|Preservative||0.02% Sodium Azide|
|Storage||Store at -20°C/1 year.|
|Research Area||Cancer, Cell Cycle, DNA/RNA, Kinases/Phosphatases|
|Restrictions||For Research Use only|
Lou, Minter-Dykhouse, Wu et al.: "MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways." in: Nature, Vol. 421, Issue 6926, pp. 957-61, 2003 (PubMed).
Schwarz, Lovly, Piwnica-Worms: "Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation." in: Molecular cancer research : MCR, Vol. 1, Issue 8, pp. 598-609, 2003 (PubMed).
Wu, Chen: "Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36163-8, 2003 (PubMed).