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Checkpoint Kinase 2 (CHEK2) (pSer516) antibody

Details for Product No. ABIN965889
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Antigen
Synonyms CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, Cds1, Rad53, HUCDS1, Chk2, CHK-2
Epitope
pSer516
(36), (35), (28), (27), (17), (13), (13), (10), (9), (7), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(335), (146), (145), (55), (37), (36), (12), (6), (4), (1)
Host
Rabbit
(273), (68), (1)
Conjugate
Un-conjugated
(7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(259), (123), (83), (66), (60), (40), (28), (28), (9), (4), (2), (1), (1)
Pubmed 3 references available
Quantity 100 µg
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Availability Will be delivered in 5 to 7 Business Days
Catalog No. ABIN965889
385.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Chk2 around the phosphorylation site of serine 516 (Q-P-SP-T-S).
Specificity Chk2 (phospho-Ser516) antibody detects endogenous levels of Chk2 only when phosphorylated at serine 516.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Chk2
Research Area Cancer, Cell Cycle, DNA/RNA, Kinases/Phosphatases
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Lou, Minter-Dykhouse, Wu et al.: "MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways." in: Nature, Vol. 421, Issue 6926, pp. 957-61, 2003 (PubMed).

Schwarz, Lovly, Piwnica-Worms: "Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation." in: Molecular cancer research : MCR, Vol. 1, Issue 8, pp. 598-609, 2003 (PubMed).

Wu, Chen: "Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36163-8, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN965889
385.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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