Cholinergic Receptor, Muscarinic 2 (CHRM2) (C-Term,AA 451-466) antibody

Antigen: Cholinergic Receptor, Muscarinic 2 (CHRM2)

Synonyms: HM2, FLJ43243, MGC120006, MGC120007, M2, Chrm-2, chrm2, CHRM2

Binding Site: C-Term,AA 451-466

Clonality: Polyclonal

Host: Please enquire

Reactivity: Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN965894

Additional Information

Alternative name: CHRM2

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human CHRM2(451-466aa), identical to the related rat sequence.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Description: The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor. The M2 muscarinic receptors are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system, by slowing the speed of depolarization. The CHRM2 gene inhibits the release of acetylcholine from cholinergic fibers in the lungs and elsewhere. In airway parasympathetic neurons, it is decreased by viral infections and by interferon-gamma, increasing actylcholine release. This gene is thought to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing. In a sample of 667 individuals from 304 families, Gosso MF et al. genotyped three single-nucleotide polymorphisms (SNPs) in the CHRM2 gene on 7q31-35. CHRM2 is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.

Application Details

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: 0.05mg Thiomersal, 0.05mg NaN3.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month.

Restrictions: For Research Use only

Publications

Product: Zhou, Fryer, Jacoby: "Structure of the human M(2) muscarinic acetylcholine receptor gene and its promoter." in: Gene, Vol. 271, Issue 1, pp. 87-92, 2001 (PubMed).

Wang, Hinrichs, Stock et al.: "Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome." in: Human molecular genetics, Vol. 13, Issue 17, pp. 1903-11, 2004 (PubMed).

Luo, Kranzler, Zuo et al.: "CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study." in: Human molecular genetics, Vol. 14, Issue 16, pp. 2421-34, 2005 (PubMed).

Monaco, Zanusso, Mazzucco et al.: "Cerebral amyloidoses: molecular pathways and therapeutic challenges." in: Current medicinal chemistry, Vol. 13, Issue 16, pp. 1903-13, 2006 (PubMed).

Gosso, van Belzen, de Geus et al.: "Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families." in: Genes, brain, and behavior, Vol. 5, Issue 8, pp. 577-84, 2006 (PubMed).