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CHUK antibody (conserved Helix-Loop-Helix Ubiquitous Kinase) (AA 500-590)

Details for Product anti-CHUK Antibody No. ABIN965896, Supplier: Log in to see
Antigen
  • AI256658
  • CHUK
  • Chuk1
  • Fbx24
  • Fbxo24
  • IKBKA
  • ikk
  • IKK-alpha
  • IKK1
  • ikk1
  • Ikka
  • IKKA
  • ikka
  • ikkalpha
  • NFKBIKA
  • TCF16
  • zgc:56539
Alternatives
anti-Human CHUK antibody for Western Blotting
Epitope
AA 500-590
63
29
23
17
15
15
13
13
12
11
10
9
9
8
8
7
7
6
5
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
339
129
84
19
4
4
Host
Mouse
271
72
11
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CHUK antibody is un-conjugated
15
11
10
9
8
8
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
303
144
95
64
55
47
37
26
22
10
4
4
2
2
1
1
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of CHUK (aa500-590) expressed in E. Coli.
Clone 7C10B6-1A10A10
Isotype IgG1
Purification Ascitic fluid
Alternative Name CHUK (CHUK Antibody Abstract)
Background CHUK: conserved helix-loop-helix ubiquitous kinase. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Synonyms: IKK1, IKKA, IKBKA
Gene ID 1147
Pathways PI3K-Akt Signaling, NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Park, Krishnan, OMalley, Yamamoto, Gaynor: "Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation." in: Molecular cell, Vol. 18, Issue 1, pp. 71-82, 2005

Prajapati, Verma, Yamamoto, Kwak, Gaynor: "Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1739-46, 2004

Background publications Soond, Terry, Colbert, Riches: "TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB." in: Molecular and cellular biology, Vol. 23, Issue 22, pp. 8334-44, 2003