CHUK antibody (conserved Helix-Loop-Helix Ubiquitous Kinase) (AA 500-590)

Details for Product anti-CHUK Antibody No. ABIN965896, Supplier: Log in to see
Antigen
  • ikk
  • ikk1
  • ikka
  • ikkalpha
  • CHUK
  • IKBKA
  • IKK-alpha
  • IKK1
  • IKKA
  • NFKBIKA
  • TCF16
  • AI256658
  • Chuk1
  • Fbx24
  • Fbxo24
  • Ikka
  • zgc:56539
  • conserved helix-loop-helix ubiquitous kinase
  • chuk
  • CHUK
  • Chuk
Alternatives
anti-Human CHUK antibody for Western Blotting
Epitope
AA 500-590
51
32
17
17
15
15
11
11
10
9
9
8
8
8
7
7
7
7
6
5
4
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
353
154
105
20
12
11
10
7
6
5
5
4
2
1
Host
Mouse
274
82
12
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CHUK antibody is un-conjugated
15
11
11
9
8
8
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
318
150
95
78
62
48
44
29
26
19
9
5
3
3
2
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of CHUK (aa500-590) expressed in E. Coli.
Clone 7C10B6-1A10A10
Isotype IgG1
Purification Ascitic fluid
Alternative Name CHUK (CHUK Antibody Abstract)
Background CHUK: conserved helix-loop-helix ubiquitous kinase. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Synonyms: IKK1, IKKA, IKBKA
Gene ID 1147
Pathways PI3K-Akt Signaling, NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Park, Krishnan, OMalley, Yamamoto, Gaynor: "Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation." in: Molecular cell, Vol. 18, Issue 1, pp. 71-82, 2005 (PubMed).

Prajapati, Verma, Yamamoto, Kwak, Gaynor: "Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1739-46, 2004 (PubMed).

Background publications Soond, Terry, Colbert, Riches: "TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB." in: Molecular and cellular biology, Vol. 23, Issue 22, pp. 8334-44, 2003 (PubMed).

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