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Cortactin antibody (CTTN) (pTyr466)

Details for Product anti-CTTN Antibody No. ABIN965920, Supplier: Log in to see
Antigen
  • 1110020L01Rik
  • CG3637
  • cortactin
  • Cttn
  • CTTN
  • cttn
  • CTTN1
  • Cttnb
  • Dmel\CG3637
  • EMS1
  • Ems1
  • ems1
  • P85.25
Alternatives
anti-Mouse (Murine) Cortactin antibody for Western Blotting
Epitope
pTyr466
28
25
17
15
14
12
9
7
6
6
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
179
105
60
8
7
5
3
2
2
1
1
1
1
1
1
Host
Rabbit
165
25
15
Conjugate
This Cortactin antibody is un-conjugated
4
4
4
4
4
4
Application
Immunohistochemistry (IHC)
171
88
85
22
16
9
7
3
3
2
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from mouse Cortactin around the phosphorylation site of tyrosine 466 (P-V-YP-E-T).
Specificity Cortactin (Phospho-Tyr466) antibody detects endogenous levels of Cortactin only when phosphorylated at tyrosine 466.
Alternative Name Cortactin (CTTN Antibody Abstract)
Research Area Cancer, Cell Cycle, Cytoskeleton, Microfilaments
Pathways MAPK Signaling
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Luo, Pan, Mines, Watson, Zhang, Fan: "CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis." in: The Journal of biological chemistry, Vol. 281, Issue 40, pp. 30081-93, 2006

Kinley, Weed, Weaver, Karginov, Bissonette, Cooper, Parsons: "Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion." in: Current biology : CB, Vol. 13, Issue 5, pp. 384-93, 2003

Background publications Head, Jiang, Li, Zorn, Schaefer, Parsons, Weed: "Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton." in: Molecular biology of the cell, Vol. 14, Issue 8, pp. 3216-29, 2003

Li, Liu, Zhan: "Tyrosine phosphorylation of cortactin is required for H2O2-mediated injury of human endothelial cells." in: The Journal of biological chemistry, Vol. 275, Issue 47, pp. 37187-93, 2001