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Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (N-Term) antibody

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Antigen
  • CEF147
  • COII
  • COX-2
  • Cox-2
  • cox-2
  • Cox2
  • cox2
  • COX2
  • gripghs
  • GRIPGHS
  • hCox-2
  • hcox-2
  • PGG/HS
  • pgg/hs
  • pghs-2
  • PGHS-2
  • PGHS2
  • Pghs2
  • PHS-2
  • phs-2
  • PHSII
  • PTGS2
  • TIS10
Epitope
N-Term
60
16
15
14
14
12
11
9
8
5
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
200
87
83
6
5
5
4
3
2
1
1
Host
Rabbit
161
53
15
Clonality
Polyclonal
Conjugate
Un-conjugated
11
7
4
4
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
153
67
66
59
24
24
20
13
13
11
9
2
2
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human COX-2, different from the related rat sequence by two amino acids.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 2 (PTGS2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Alternative Name Prostaglandin G/H synthase 2 (PTGS2 Antibody Abstract)
Background Cyclooxygenase (Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms, Cox-1 and Cox-2, have been identified. Cox-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis. This gene is localized to sites associated with retinal blood vessels, and plays an important role in blood vessel formation in the retina. And the glucocorticoid receptor suppression of COX-2 is also crucial for curtailing lethal immune activation, and suggest new therapeutic approaches for regulation of T-cell-mediated inflammatory diseases.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Wilkinson-Berka, Alousis, Kelly, Gilbert: "COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity." in: Investigative ophthalmology & visual science, Vol. 44, Issue 3, pp. 974-9, 2003 (PubMed).

Brewer, Khor, Vogt, Muglia, Fujiwara, Haegele, Sleckman, Muglia: "T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation." in: Nature medicine, Vol. 9, Issue 10, pp. 1318-22, 2003 (PubMed).

Liu, Chang, Narko, Trifan, Wu, Smith, Haudenschild, Lane, Hla: "Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice." in: The Journal of biological chemistry, Vol. 276, Issue 21, pp. 18563-9, 2001 (PubMed).

Background publications Salmenkivi, Haglund, Ristimäki, Arola, Heikkilä: "Increased expression of cyclooxygenase-2 in malignant pheochromocytomas." in: The Journal of clinical endocrinology and metabolism, Vol. 86, Issue 11, pp. 5615-9, 2001 (PubMed).