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CAMP Responsive Element Binding Protein 1 (CREB1) (pSer129) antibody

Antigen

CAMP Responsive Element Binding Protein 1 (CREB1)
Synonyms CREB, MGC9284, Creb, Creb-1, AV083133, 2310001E10Rik, 3526402H21Rik, JAL, hJAL, ATCE1, CREB3, CREB4, AIBZIP, CREB1, creb1, MGC52669, creb, MGC69285, MGC55598, zgc:55598, Creb1, DKFZp468J2311
Binding Site
Alternatives

pSer129
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
3 references available
Catalog no. ABIN965924
Quantity 100ug  (100ug/100ul.)  (Variants)
Price 385.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name CREB
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human CREB around the phosphorylation site of serine 129 (I-L-SP-R-R).
Specificity CREB (phospho-Ser129) antibody detects endogenous levels of CREB only when phosphorylated at serine 129.

Application Details
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Application Notes IHC: 1:50-1:100.
Concentration 100ug/100ul.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Research Area Immunology, Innate Immunity, Transcription Factors
Restrictions For Research Use only

Publications
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Product Tyson, Swarthout, Jefcoat et al.: "PTH induction of transcriptional activity of the cAMP response element-binding protein requires the serine 129 site and glycogen synthase kinase-3 activity, but not casein kinase II sites." in: Endocrinology, Vol. 143, Issue 2, pp. 674-82, 2002 (PubMed).

Rothem, Stark, Assaraf: "Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene." in: Molecular pharmacology, Vol. 66, Issue 6, pp. 1536-43, 2004 (PubMed).

Garat, Fankell, Erickson et al.: "Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells." in: Molecular and cellular biology, Vol. 26, Issue 13, pp. 4934-48, 2006 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "CAMP Responsive Element Binding Protein 1 (CREB1)", type "Antibodies"
Hosts Rabbit (171), Mouse (50)
Reactivities Human (206), Rat (Rattus) (128), Mouse (Murine) (113), Cow (Bovine) (59), Pig (Porcine) (59), Sheep (Ovine) (56), Chicken (55), Dog (Canine) (46), Horse (Equine) (15), Monkey (4), Xenopus laevis (2), Zebrafish (2), Cat (Feline) (1)
Applications Western Blotting (WB) (140), ELISA (71), Immunofluorescence (IF) (69), Immunohistochemistry (IHC) (69), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (41), Immunoprecipitation (IP) (20), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Flow Cytometry (FACS) (5), Immunocytochemistry (ICC) (5), Gel Shift (GS) (2), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2), Dot Blot (Dot) (1)
Conjugates Alexa Fluor 488 (7), Alexa Fluor 350 (6), Alexa Fluor 555 (6), Alexa Fluor 647 (6), PE,Cy5.5 (6), Biotin (5), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2)
Epitopes pSer133 (47), pSer129 (17), pSer142 (9), N-Term (7), Ser129 (5), pSer121 (5), Internal Region (4), Ser133 (4), Center (2), pS133 (2), phosphospecific (2), AA 1-96 (1), AA 100-150 (1), AA 122-147,pSer133 (1), AA 136-341 (1), AA 152-179 (1), AA 5-24 (1), AA 5-45 (1), Ser142 (1), Thr100 (1), pSer129, pSer133 (1), pThr100 (1), pThr244 (1), pTyr766 (1)