CAMP Responsive Element Binding Protein 1 (CREB1) (pSer129) antibody

Details for Product No. ABIN965924
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Antigen
Synonyms creb, CREB1, Creb1, CREB, 2310001E10Rik, 3526402H21Rik, AV083133, Creb, Creb-1, creb1, zgc:55598
Epitope
pSer129
(80), (35), (28), (20), (19), (16), (15), (8), (8), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(370), (242), (228), (75), (69), (68), (45), (9), (6), (6), (5), (1), (1), (1), (1)
Host
Rabbit
(330), (55), (2), (1)
Conjugate
Un-conjugated
(11), (9), (9), (7), (6), (6), (6), (6), (6), (6), (6), (2), (2), (2)
Application
Immunohistochemistry (IHC)
(292), (155), (148), (74), (60), (46), (32), (30), (14), (4), (2), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 100 μg
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Catalog No. ABIN965924
398.75 $
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human CREB around the phosphorylation site of serine 129 (I-L-SP-R-R).
Specificity CREB (phospho-Ser129) antibody detects endogenous levels of CREB only when phosphorylated at serine 129.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Alternative Name CREB
Research Area Immunology, Innate Immunity, Transcription Factors
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Tyson, Swarthout, Jefcoat et al.: "PTH induction of transcriptional activity of the cAMP response element-binding protein requires the serine 129 site and glycogen synthase kinase-3 activity, but not casein kinase II sites." in: Endocrinology, Vol. 143, Issue 2, pp. 674-82, 2002 (PubMed).

Rothem, Stark, Assaraf: "Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene." in: Molecular pharmacology, Vol. 66, Issue 6, pp. 1536-43, 2004 (PubMed).

Garat, Fankell, Erickson et al.: "Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells." in: Molecular and cellular biology, Vol. 26, Issue 13, pp. 4934-48, 2006 (PubMed).

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