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EGFR antibody (Epidermal Growth Factor Receptor) (pSer1070)

Details for Product anti-EGFR Antibody No. ABIN966032, Supplier: Log in to see
Antigen
  • 9030024J15Rik
  • AI552599
  • C-erb
  • c-erbB
  • CG10079
  • D-Egf
  • d-egf-r
  • D-EGFR
  • Degfr
  • dEgfr
  • DEgfr
  • DEGFR
  • dEGFR
  • dEGFR1
  • der
  • DER
  • Der
  • DER/EGFR
  • DER/faint little ball
  • DER/top
  • DER/torpedo
  • DER1
  • DER flb
  • Dmel\\CG10079
  • DmHD-33
  • EFG-R
  • Egf
  • EGF-R
  • Egf-r
  • EgfR
  • EGfr
  • EGFr
  • EGFR
  • egfr
  • egfr1
  • EGFR12
  • EGFR15
  • EK2-6
  • El
  • Elp
  • Elp-1
  • Elp-B1
  • Elp-B1RB1
  • ERBB
  • Erbb
  • ErbB-1
  • ERBB1
  • Erbb2
  • Errb1
  • Errp
  • flb
  • HD-33
  • HER1
  • l(2)05351
  • l(2)09261
  • l(2)57DEFa
  • l(2)57Ea
  • l(2)57EFa
  • mENA
  • mor1
  • PIG61
  • TOP
  • top
  • top/DER
  • top/flb
  • Torpedo/DER
  • Torpedo/Egfr
  • torpedo/Egfr
  • torpedo/egfr
  • wa-2
  • wa2
  • Wa5
Alternatives
anti-Human EGFR antibody for Western Blotting
Epitope
pSer1070
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139
58
57
53
51
51
48
46
45
44
43
36
33
32
30
30
25
25
23
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22
19
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4
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3
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2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
1
1
1
1
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1
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1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
2173
747
608
23
16
14
13
10
8
5
4
2
1
1
1
1
1
Host
Rabbit
1376
696
69
45
7
2
Conjugate
This EGFR antibody is un-conjugated
94
74
64
57
46
44
25
24
23
21
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21
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21
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20
20
19
19
19
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19
19
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19
16
2
2
2
2
1
Application
Immunohistochemistry (IHC)
1330
577
526
446
426
245
232
185
87
74
73
55
25
11
11
8
6
6
4
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human EGFR around the phosphorylation site of serine 1070 (R-Y-SP-S-D).
Specificity EGFR (phospho-Ser1070) antibody detects endogenous levels of EGFR only when phosphorylated at serine1070.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name EGFR (EGFR Antibody Abstract)
Research Area Cancer, Tyrosine Kinases, Growth Factors, Hormones, Receptors
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Feinmesser, Wicks, Taverner, Chantry: "Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation." in: The Journal of biological chemistry, Vol. 274, Issue 23, pp. 16168-73, 1999 (PubMed).

Background publications Gamou, Shimizu: "Hydrogen peroxide preferentially enhances the tyrosine phosphorylation of epidermal growth factor receptor." in: FEBS letters, Vol. 357, Issue 2, pp. 161-4, 1995 (PubMed).

Gamou, Shimizu: "Calphostin-C stimulates epidermal growth factor receptor phosphorylation and internalization via light-dependent mechanism." in: Journal of cellular physiology, Vol. 158, Issue 1, pp. 151-9, 1994 (PubMed).

Heisermann, Gill: "Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo." in: The Journal of biological chemistry, Vol. 263, Issue 26, pp. 13152-8, 1988 (PubMed).