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EGFR antibody (Epidermal Growth Factor Receptor) (pSer1070)

Details for Product anti-EGFR Antibody No. ABIN966032, Supplier: Login to see New
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Antigen
Synonyms
C-erb, CG10079, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DER1, DEgfr, Degfr, Der, DmHD-33, Dmel\\CG10079, EFG-R, EGF-R, EGFR, EGFr, EGfr, EK2-6, Egf,  ... show more
C-erb, CG10079, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DER1, DEgfr, Degfr, Der, DmHD-33, Dmel\\CG10079, EFG-R, EGF-R, EGFR, EGFr, EGfr, EK2-6, Egf, Egf-r, EgfR, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, HD-33, TOP, Torpedo/DER, Torpedo/Egfr, c-erbB, d-egf-r, dEGFR, dEGFR1, dEgfr, der, egfr, flb, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57EFa, l(2)57Ea, mor1, top, top/DER, top/flb, torpedo/Egfr, torpedo/egfr, EGFR12, EGFR15, egfr1, Erbb2, ERBB, ERBB1, HER1, PIG61, mENA, ErbB-1, Errp, 9030024J15Rik, AI552599, Erbb, Errb1, Wa5, wa-2, wa2 show less
Alternatives
Epitope
pSer1070
(141), (64), (61), (60), (56), (55), (50), (50), (48), (48), (47), (33), (33), (30), (30), (26), (24), (24), (24), (22), (21), (20), (19), (18), (17), (16), (16), (15), (15), (13), (13), (13), (13), (13), (13), (13), (12), (10), (10), (10), (10), (9), (9), (9), (9), (9), (9), (8), (8), (8), (8), (6), (6), (6), (6), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(1865), (688), (601), (21), (15), (13), (13), (11), (7), (6), (5), (2), (2), (2), (1), (1)
Host
Rabbit
(1368), (445), (41), (27), (6), (3)
Conjugate
This EGFR antibody is un-conjugated
(84), (59), (45), (35), (26), (25), (25), (23), (21), (21), (21), (21), (21), (21), (20), (2), (2), (1)
Application
Immunohistochemistry (IHC)
(1225), (518), (401), (306), (256), (236), (201), (171), (86), (81), (73), (61), (25), (19), (11), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human EGFR around the phosphorylation site of serine 1070 (R-Y-SP-S-D).
Specificity EGFR (phospho-Ser1070) antibody detects endogenous levels of EGFR only when phosphorylated at serine1070.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name EGFR (EGFR Antibody Abstract)
Research Area Cancer, Tyrosine Kinases, Growth Factors, Hormones, Receptors
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Feinmesser, Wicks, Taverner et al.: "Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation." in: The Journal of biological chemistry, Vol. 274, Issue 23, pp. 16168-73, 1999 (PubMed).

Background publications Gamou, Shimizu: "Hydrogen peroxide preferentially enhances the tyrosine phosphorylation of epidermal growth factor receptor." in: FEBS letters, Vol. 357, Issue 2, pp. 161-4, 1995 (PubMed).

Gamou, Shimizu: "Calphostin-C stimulates epidermal growth factor receptor phosphorylation and internalization via light-dependent mechanism." in: Journal of cellular physiology, Vol. 158, Issue 1, pp. 151-9, 1994 (PubMed).

Heisermann, Gill: "Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo." in: The Journal of biological chemistry, Vol. 263, Issue 26, pp. 13152-8, 1988 (PubMed).

Catalog No. ABIN966032
$398.75
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