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Elf4 (N-Term) antibody

Details for Product No. ABIN966055, Supplier: Log in to see
Antigen
  • ELFR
  • MEF
  • AV314029
  • BC042423
  • ENSMUSG00000053512
  • Gm9907
  • Mef
  • RGD1560743
  • FMF
  • TRIM20
Epitope
N-Term
26
16
11
7
4
3
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
82
20
11
3
3
2
Host
Rabbit
79
4
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
73
40
6
6
5
4
3
1
1
Supplier
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human ELF4 (ETS-related transcription factor Elf-4)
Purification Purified by antigen-specific affinity chromatography.
Background ELF4 (ETS-related transcription factor Elf-4) is a transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. It acts synergistically with RUNX1 to transactivate the IL3 promoter. ELF4 also transactivates the PRF1 promoter in natural killer (NK) cells. The protein plays a role in the development and function of NK and NK T-cells and in innate immunity. ELF4 interacts via an N-terminal region with the RUNX1 Runt domain and interacts via its C-terminus with PML, this interaction enhances ELF4 transactivation of the bovine lysozyme gene.
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Suico, Yoshida, Seki et al.: "Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein." in: The Journal of biological chemistry, Vol. 279, Issue 18, pp. 19091-8, 2004 (PubMed).

Cho, Akbarali, Zerbini et al.: "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene." in: The Journal of biological chemistry, Vol. 279, Issue 19, pp. 19512-22, 2004 (PubMed).

Suico, Koyanagi, Ise et al.: "Functional dissection of the ETS transcription factor MEF." in: Biochimica et biophysica acta, Vol. 1577, Issue 1, pp. 113-20, 2002 (PubMed).

Mao, Frank, Zhang et al.: "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias." in: Molecular and cellular biology, Vol. 19, Issue 5, pp. 3635-44, 1999 (PubMed).