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Estrogen Receptor alpha antibody (Estrogen Receptor 1) (AA 410-592)

Details for Product anti-ESR1 Antibody No. ABIN966081, Supplier: Log in to see
Antigen
  • ACTGP1
  • ACT1GP1
  • HY-psi-gamma-AC6
  • ER[b]2
  • ER[b]a
  • zfER[b]2
  • zfER-beta2
  • XER
  • era
  • esr
  • esra
  • nr3a1
  • ERbeta
  • xesr-1
  • ERalpha
  • xlERalpha1
  • xlERalpha2
  • LOC398733
  • LOC398734
  • 2610524P08Rik
  • 9130407C09Rik
  • AU019798
  • Era
  • M-ERA
  • MERA-S
  • MERA-W
  • ERA
  • ERAL1A
  • H-ERA
  • HERA-A
  • HERA-B
  • er
  • esr1
  • ER
  • ESR
  • ESRA
  • ESTRR
  • NR3A1
  • ER-alpha
  • Esr
  • RNESTROR
  • ERALPHA
  • ER[a]
  • eralpha
  • zfER[a]
  • ESR1
  • AA420328
  • AU041214
  • ERa
  • Estr
  • Estra
  • Nr3a1
Alternatives
anti-Human Estrogen Receptor alpha antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 410-592
89
44
44
42
36
31
27
26
22
20
20
17
17
16
16
15
14
13
13
13
10
10
9
9
9
8
8
8
7
6
6
6
5
5
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
803
279
167
27
11
11
11
7
6
4
3
2
1
1
Host
Mouse
622
220
8
3
2
Clonality (Clone)
Monoclonal ()
Conjugate
This Estrogen Receptor alpha antibody is un-conjugated
31
30
27
15
14
14
10
8
8
8
8
8
8
8
8
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
613
268
267
154
113
92
68
30
23
14
12
9
9
6
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
Supplier
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Immunogen Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli.
Clone 2B7
Isotype IgG1
Purification Purified
Alternative Name ER-alpha (ESR1 Antibody Abstract)
Background The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.
Synonyms: ER, ESR1, Era, ESRA
Gene ID 2099
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Buffer PBS
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Pertschuk, Masood, Simone et al.: "Estrogen receptor immunocytochemistry in endometrial carcinoma: a prognostic marker for survival." in: Gynecologic oncology, Vol. 63, Issue 1, pp. 28-33, 1996 (PubMed).

Pertschuk, Feldman, Kim et al.: "Estrogen receptor immunocytochemistry in paraffin embedded tissues with ER1D5 predicts breast cancer endocrine response more accurately than H222Sp gamma in frozen sections or cytosol-based ligand-binding assays." in: Cancer, Vol. 77, Issue 12, pp. 2514-9, 1996 (PubMed).

Background publications Paech, Webb, Kuiper et al.: "Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites." in: Science (New York, N.Y.), Vol. 277, Issue 5331, pp. 1508-10, 1997 (PubMed).