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Chromosome 14 Open Reading Frame 1 (C14orf1) (N-Term) antibody

Details for Product No. ABIN966089, Supplier: Log in to see
Antigen
  • ERG28
  • NET51
  • homolog of yeast ergosterol28
  • T27I1.5
  • T27I1_5
  • C7H14orf1
Epitope
N-Term
6
5
2
Reactivity
Mouse (Murine), Human
14
2
2
2
2
2
2
2
1
1
1
1
1
Host
Rabbit
15
Clonality
Polyclonal
Application
Immunohistochemistry (IHC)
9
5
1
1
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of mouse ERG28(Probable ergosterol biosynthetic protein 28)
Purification Purified by antigen-specific affinity chromatography.
Alternative Name ERG28
Background ERG28(Probable ergosterol biosynthetic protein 28) has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. ERG28 may also be responsible for facilitating their interaction. The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. ERG28 interacts with ERG25, ERG26 and ERG27. It also interacts with ERG1, ERG3, ERG5, ERG6 and ERG11.
Research Area Signaling, Metabolism
Application Notes ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions For Research Use only
Format Liquid
Buffer This antibody is stored in PBS, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Mo, Valachovic, Bard: "The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p)." in: Biochimica et biophysica acta, Vol. 1686, Issue 1-2, pp. 30-6, 2004 (PubMed).

Background publications Ghaemmaghami, Huh, Bower et al.: "Global analysis of protein expression in yeast." in: Nature, Vol. 425, Issue 6959, pp. 737-41, 2003 (PubMed).

Mo, Valachovic, Randall et al.: "Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 15, pp. 9739-44, 2002 (PubMed).

Gachotte, Eckstein, Barbuch et al.: "A novel gene conserved from yeast to humans is involved in sterol biosynthesis." in: Journal of lipid research, Vol. 42, Issue 1, pp. 150-4, 2001 (PubMed).

Ottolenghi, Daizadeh, Ju et al.: "The genomic structure of c14orf1 is conserved across eukarya." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 11, Issue 9, pp. 786-8, 2000 (PubMed).