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FAK antibody (PTK2 Protein tyrosine Kinase 2) (pTyr925)

Details for Product anti-PTK2 Antibody No. ABIN966122, Supplier: Login to see
Antigen
  • FADK
  • FAK
  • FAK1
  • FRNK
  • PPP1R71
  • p125FAK
  • pp125FAK
  • Fadk
  • mKIAA4203
Epitope
pTyr925
69
61
58
50
45
32
22
22
20
15
14
14
13
13
13
13
11
9
9
8
7
7
7
7
6
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
638
357
330
21
6
5
3
3
2
2
2
1
1
1
Host
Rabbit
579
92
2
2
1
Conjugate
This FAK antibody is un-conjugated
18
17
16
13
12
12
11
11
11
11
11
11
3
2
2
1
Application
Immunohistochemistry (IHC)
468
182
154
124
103
84
54
24
15
7
6
5
4
3
2
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human FAK around the phosphorylation site of tyrosine 925 (K-V-YP-E-N).
Specificity FAK (phospho-Tyr925) antibody detects endogenous levels of FAK only when phosphorylated at tyrosine 925.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name FAK (PTK2 Antibody Abstract)
Research Area Cancer, Extracellular Matrix, Tyrosine Kinases, Angiogenesis, Kinases/Phosphatases
Pathways
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Toriumi, Hiraoka, Watanabe et al.: "Pioglitazone reduces monocyte adhesion to vascular endothelium under flow by modulating RhoA GTPase and focal adhesion kinase." in: FEBS letters, Vol. 553, Issue 3, pp. 419-22, 2003 (PubMed).

Background publications Sanders, Basson: "p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV." in: The Journal of biological chemistry, Vol. 280, Issue 25, pp. 23516-22, 2005 (PubMed).

Cherubini, Hofmann, Pillozzi et al.: "Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling." in: Molecular biology of the cell, Vol. 16, Issue 6, pp. 2972-83, 2005 (PubMed).