anti-FAK antibody (PTK2 Protein tyrosine Kinase 2) (pTyr925)

Details for Product anti-PTK2 Antibody No. ABIN966122
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Antigen
Synonyms FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, Fadk, mKIAA4203
Epitope
pTyr925
(67), (60), (60), (57), (49), (30), (26), (21), (21), (15), (14), (13), (12), (12), (11), (10), (9), (9), (8), (8), (7), (7), (7), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(687), (409), (378), (23), (5), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(632), (86), (2), (1)
Conjugate
This FAK antibody is un-conjugated
(17), (17), (16), (13), (13), (12), (12), (12), (12), (12), (12), (3), (2), (2), (1)
Application
Immunohistochemistry (IHC)
(517), (221), (183), (121), (106), (87), (51), (21), (11), (7), (6), (5), (5), (3), (3), (3), (2), (1)
Pubmed 3 references available
Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human FAK around the phosphorylation site of tyrosine 925 (K-V-YP-E-N).
Specificity FAK (phospho-Tyr925) antibody detects endogenous levels of FAK only when phosphorylated at tyrosine 925.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name FAK (PTK2 Antibody Abstract)
Research Area Cancer, Extracellular Matrix, Tyrosine Kinases, Angiogenesis, Kinases/Phosphatases
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Toriumi, Hiraoka, Watanabe et al.: "Pioglitazone reduces monocyte adhesion to vascular endothelium under flow by modulating RhoA GTPase and focal adhesion kinase." in: FEBS letters, Vol. 553, Issue 3, pp. 419-22, 2003 (PubMed).

Background publications Sanders, Basson: "p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV." in: The Journal of biological chemistry, Vol. 280, Issue 25, pp. 23516-22, 2005 (PubMed).

Cherubini, Hofmann, Pillozzi et al.: "Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling." in: Molecular biology of the cell, Vol. 16, Issue 6, pp. 2972-83, 2005 (PubMed).

Validation Images
Catalog No. ABIN966122
398.75 $
Plus shipping costs $45.00
Quantity
Price
100 μg
398.75 $

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