Fanconi Anemia Complementation Group G (FANCG) (C-Term,pSer383) antibody

Antigen: Fanconi Anemia Complementation Group G (FANCG)

Synonyms: FAG, XRCC9, fancg

Binding Site: C-Term,pSer383

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966130

Additional Information

Alternative name: FANCG

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human FANCG (Fanconi anemia group G protein)

Description: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. FANCG may be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCG is a andidate tumor suppressor gene. FANCG belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. The major form is nuclear. The minor form is cytoplasmic. Highly expressed in testis and thymus. Found in lymphoblasts. Defects in FANCG are a cause of Fanconi anemia (FA)

Application Details

Research Area: Chromatin and Nuclear Signaling, DNA/RNA

Restrictions: For Research Use only

Publications

Product: Liu, Lamerdin, Tucker et al.: "The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 17, pp. 9232-7, 1997 (PubMed).

Garcia-Higuera, Kuang, Näf et al.: "Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex." in: Molecular and cellular biology, Vol. 19, Issue 7, pp. 4866-73, 1999 (PubMed).

Demuth, Wlodarski, Tipping et al.: "Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9." in: European journal of human genetics : EJHG, Vol. 8, Issue 11, pp. 861-8, 2000 (PubMed).

Meetei, Sechi, Wallisch et al.: "A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome." in: Molecular and cellular biology, Vol. 23, Issue 10, pp. 3417-26, 2003 (PubMed).

Meetei, Levitus, Xue et al.: "X-linked inheritance of Fanconi anemia complementation group B." in: Nature genetics, Vol. 36, Issue 11, pp. 1219-24, 2004 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).