GSK3a
Reactivity: Human
WB, ELISA, IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Western Blot: 1: 500- 1: 2,000 IHC(P): 1: 500- 1: 2,000 IHC(F): 1: 500- 1: 2,000 ELISA: Propose dilution 1: 10,000. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Format
Liquid
Storage
-20 °C
Sayas, Ariaens, Ponsioen, Moolenaar: "GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction." in: Molecular biology of the cell, Vol. 17, Issue 4, pp. 1834-44, (2006) (PubMed).
Bradley, Currie, MacMillan, Muir, McCarron: "Cyclic ADP-ribose increases Ca2+ removal in smooth muscle." in: Journal of cell science, Vol. 116, Issue Pt 21, pp. 4291-306, (2003) (PubMed).
GSK3 alpha (Glycogen synthase kinase 3 alpha), with 483-amino acid protein (about 53kDa), belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily,GSK3 subsubfamily, which also includes GSK3 beta.GSK3 is a multifunctional serine/threonine kinase that is usually inactivated by serine phosphorylation in response to extracellular cues. GSK3 is a key regulator of numerous signalling pathways, including cellular responses to Wnt, receptor tyrosine kinases and G-protein-coupled receptors and is involved in a wide range of cellular processes, ranging from glycogen metabolism to cell cycle regulation and proliferation.GSK3 alpha is implicated in the control of several regulatory proteins including glycogen synthase and transcription factors.