GSK3 alpha antibody (Glycogen Synthase Kinase 3 alpha) (pSer21)

Details for Product anti-GSK3a Antibody No. ABIN966232, Supplier: Log in to see
Antigen
  • GSK3A
  • CG5182
  • Dmel\\CG5182
  • GSK3a
  • 2700086H06Rik
  • xgsk3
  • GSK-3[a]
  • GSK-3[b]
  • GSK3
  • gsk3a
  • glycogen synthase kinase 3 alpha
  • CG5182 gene product from transcript CG5182-RA
  • glycogen synthase kinase 3 alpha b
  • GSK3A
  • gsk3a
  • Bm1_31380
  • Pk34A
  • Gsk3a
  • LOC100339192
  • gsk3ab
Alternatives
anti-Human GSK3 alpha antibody for Western Blotting
Epitope
pSer21
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Conjugate
This GSK3 alpha antibody is un-conjugated
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Application
Immunohistochemistry (IHC)
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Options
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human GSK3 around the phosphorylation site of serine 21 (T-S-SP-F-A).
Specificity GSK3 (phospho-Ser21) antibody detects endogenous levels of GSK3 only when phosphorylated at serine 21.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name GSK3alpha (GSK3a Antibody Abstract)
Pathways PI3K-Akt Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Welsh, Wilson, Proud: "GSK3: a SHAGGY frog story." in: Trends in cell biology, Vol. 6, Issue 7, pp. 274-9, 2004 (PubMed).

Barry, Graham, Fry, Gibbins: "Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?" in: FEBS letters, Vol. 553, Issue 1-2, pp. 173-8, 2003 (PubMed).

Koivisto, Alavian, Hakkinen, Pelech, McCulloch, Larjava: "Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes." in: Journal of cell science, Vol. 116, Issue Pt 18, pp. 3749-60, 2003 (PubMed).

Product cited in: Leadbetter: "Cultivation of recalcitrant microbes: cells are alive, well and revealing their secrets in the 21st century laboratory." in: Current opinion in microbiology, Vol. 6, Issue 3, pp. 274-81, 2003 (PubMed).

Srivastava, Pandey: "Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin." in: Molecular and cellular biochemistry, Vol. 182, Issue 1-2, pp. 135-41, 1999 (PubMed).

Pandey, Anand-Srivastava, Srivastava: "Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation." in: Biochemistry, Vol. 37, Issue 19, pp. 7006-14, 1998 (PubMed).

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