anti-GSK3 alpha antibody (Glycogen Synthase Kinase 3 alpha) (pSer21)

Details for Product anti-GSK3a Antibody No. ABIN966232
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Antigen
Synonyms GSK3A, CG5182, Dmel\\CG5182, GSK3a, 2700086H06Rik, xgsk3, GSK-3[a], GSK-3[b], GSK3, gsk3a
Epitope
pSer21
(59), (43), (28), (15), (12), (10), (6), (6), (5), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(258), (123), (98), (5), (3), (2), (2), (2), (2), (2)
Host
Rabbit
(208), (76), (4)
Conjugate
This GSK3 alpha antibody is un-conjugated
(19), (10), (10), (6), (6), (6), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(240), (121), (117), (43), (41), (35), (14), (10), (9), (7), (5), (1), (1)
Pubmed 6 references available
Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human GSK3 around the phosphorylation site of serine 21 (T-S-SP-F-A).
Specificity GSK3 (phospho-Ser21) antibody detects endogenous levels of GSK3 only when phosphorylated at serine 21.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name GSK3alpha (GSK3a Antibody Abstract)
Pathways PI3K-Akt Signaling Pathway
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Leadbetter: "Cultivation of recalcitrant microbes: cells are alive, well and revealing their secrets in the 21st century laboratory." in: Current opinion in microbiology, Vol. 6, Issue 3, pp. 274-81, 2003 (PubMed).

Srivastava, Pandey: "Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin." in: Molecular and cellular biochemistry, Vol. 182, Issue 1-2, pp. 135-41, 1999 (PubMed).

Pandey, Anand-Srivastava, Srivastava: "Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation." in: Biochemistry, Vol. 37, Issue 19, pp. 7006-14, 1998 (PubMed).

Background publications Welsh, Wilson, Proud: "GSK3: a SHAGGY frog story." in: Trends in cell biology, Vol. 6, Issue 7, pp. 274-9, 2004 (PubMed).

Barry, Graham, Fry et al.: "Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?" in: FEBS letters, Vol. 553, Issue 1-2, pp. 173-8, 2003 (PubMed).

Koivisto, Alavian, Hakkinen et al.: "Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes." in: Journal of cell science, Vol. 116, Issue Pt 18, pp. 3749-60, 2003 (PubMed).

Validation Images
Catalog No. ABIN966232
398.75 $
Plus shipping costs $45.00
Quantity
Price
100 μg
398.75 $

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