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USP7 antibody (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated))

Details for Product anti-USP7 Antibody No. ABIN966249, Supplier: Log in to see
Antigen
  • CG1490
  • Dmel\\CG1490
  • USP7
  • 2210010O09Rik
  • AA409944
  • AA617399
  • AU019296
  • AW548146
  • C80752
  • Hausp
  • HAUSP
  • TEF1
  • UBP
  • ubiquitin-specific protease 7
  • ubiquitin specific peptidase 7 (herpes virus-associated)
  • ubiquitin specific peptidase 7
  • Usp7
  • usp7
  • USP7
Reactivity
Human
157
44
41
15
12
9
7
5
4
3
3
3
2
2
1
1
1
1
1
1
Host
Mouse
110
47
1
Clonality (Clone)
Monoclonal ()
Conjugate
This USP7 antibody is un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
137
59
47
30
25
13
13
10
6
5
3
1
1
1
Options
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Immunogen Purified recombinant fragment of human HAUSP expressed in E. Coli.
Clone 5F11
Isotype IgG1
Purification Ascitic fluid
Alternative Name HAUSP (USP7 Antibody Abstract)
Background USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
Synonyms: TEF1, HAUSP, USP7
Molecular Weight 128kDa
Gene ID 7874
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Kotoula, Krikelis, Karavasilis, Koletsa, Eleftheraki, Televantou, Christodoulou, Dimoudis, Korantzis, Pectasides, Syrigos, Kosmidis, Fountzilas: "Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)." in: BMC cancer, Vol. 12, Issue 1, pp. 342, 2012 (PubMed).

Abély: "[Treatment of airway inflammation in cystic fibrosis]." in: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Vol. 14, Issue 11, pp. 1350-5, 2007 (PubMed).

MILLER: "Observations on a case of probable bone marrow anthracosis." in: Blood, Vol. 14, pp. 1350-3, 1970 (PubMed).

Background publications Daubeuf, Singh, Tan, Liu, Federoff, Bowers, Tolba: "HSV ICP0 recruits USP7 to modulate TLR-mediated innate response." in: Blood, Vol. 113, Issue 14, pp. 3264-75, 2009 (PubMed).

Becker, Marchenko, Maurice, Moll: "Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma." in: Cell death and differentiation, Vol. 14, Issue 7, pp. 1350-60, 2007 (PubMed).