HDAC4 antibody

Catalog No. ABIN966262

Product Details anti-HDAC4 Antibody

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HDAC4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human HDAC4 expressed in E. Coli.

Clone: 7B2

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-HDAC4 antibody (ABIN966262)

Ficner: "Novel structural insights into class I and II histone deacetylases." in: Current topics in medicinal chemistry, Vol. 9, Issue 3, pp. 235-40, (2009) (PubMed).

Nishino, Miyazaki, Hoshino, Miwa, Horinouchi, Yoshida: "14-3-3 regulates the nuclear import of class IIa histone deacetylases." in: Biochemical and biophysical research communications, Vol. 377, Issue 3, pp. 852-6, (2008) (PubMed).

Target Details for HDAC4

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Alternative Name: HDAC4 (HDAC4 Products)

Synonyms: CG1770 antibody, DHDAC4 antibody, Dmel\\CG1770 antibody, GC1770 antibody, HDAC antibody, HDAC4a antibody, dHDAC4 antibody, dmHDA405 antibody, hdac4 antibody, dana_GLEANR_19966 antibody, DanaGF18710 antibody, GF18710 antibody, HDAC4 antibody, AHO3 antibody, BDMR antibody, HA6116 antibody, HD4 antibody, HDAC-4 antibody, HDAC-A antibody, HDACA antibody, 4932408F19Rik antibody, AI047285 antibody, wu:fa96d08 antibody, wu:fc56f08 antibody, zgc:152701 antibody, histone deacetylase 4 antibody, hypothetical protein antibody, Histone deacetylase 4 antibody, GF18710 gene product from transcript GF18710-RC antibody, PTRG_03699 antibody, PGTG_15512 antibody, HDAC4 antibody, Dana\GF18710 antibody, Hdac4 antibody, hdac4 antibody

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Synonyms: HD4, HDACA, HA6116, HDAC-A, KIAA0288, HDAC4

Molecular Weight: 119kDa

Gene ID: 9759

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process