HER2 antibody (V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian))

Details for Product anti-ERBB2 Antibody No. ABIN966273, Supplier: Log in to see
Antigen
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • MLN 19
  • NEU
  • NGL
  • TKR1
  • Erbb-2
  • Neu
  • c-erbB2
  • c-neu
  • mKIAA3023
  • wu:fv70f10
  • zgc:63601
  • erb2
  • erb-b2 receptor tyrosine kinase 2
  • ERBB2
  • Erbb2
  • erbb2
Alternatives
anti-Human HER2 antibody for Western Blotting
Reactivity
Human
1368
491
320
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Host
Mouse
1002
510
32
16
12
5
1
Clonality (Clone)
Monoclonal ()
Conjugate
This HER2 antibody is un-conjugated
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Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of HER-2 expressed in E. Coli.
Clone 9B9D8
Isotype IgG2b
Purification Ascitic fluid
Alternative Name HER-2 (ERBB2 Antibody Abstract)
Background The C-erbB-2 (HER-2/neu) gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Amplification or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. High levels of c-erbB-2 were associated with estrogen receptor (ER) and progesterone receptor negativity. Overexpression of the c-erbB-2 oncogene has been shown to be associated with poor prognosis in ovarian and breast cance, The level of increased Neu expression can be a predictor of disease prognosis
Synonyms: HER-2, C-erB-2, erbB-2
Gene ID 2064
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Yamauchi, Stearns, Hayes: "When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive factor in breast cancer." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 19, Issue 8, pp. 2334-56, 2001 (PubMed).

Ferrero-Poüs, Hacène, Bouchet, Le Doussal, Tubiana-Hulin, Spyratos: "Relationship between c-erbB-2 and other tumor characteristics in breast cancer prognosis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 12, pp. 4745-54, 2001 (PubMed).

Mehta, McDermott, Hieken, Marler, Patel, Wild, Das Gupta: "Plasma c-erbB-2 levels in breast cancer patients: prognostic significance in predicting response to chemotherapy." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 16, Issue 7, pp. 2409-16, 1998 (PubMed).

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