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HER2 antibody (V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian)) (pTyr1221)

Details for Product anti-ERBB2 Antibody No. ABIN966274, Supplier: Log in to see
Antigen
  • c-erbB2
  • c-neu
  • CD340
  • Erbb-2
  • HER-2
  • HER-2/neu
  • HER2
  • mKIAA3023
  • MLN 19
  • NEU
  • Neu
  • NGL
  • TKR1
Alternatives
anti-Human HER2 antibody for Western Blotting
Epitope
pTyr1221, pTyr1222
116
84
65
55
53
51
50
45
44
35
33
29
23
20
20
20
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2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
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1
1
1
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1
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Reactivity
Human
1329
425
262
24
13
4
3
3
3
3
2
2
1
1
1
Host
Rabbit
965
503
29
18
8
5
Conjugate
This HER2 antibody is un-conjugated
74
65
60
54
45
41
18
18
17
10
10
9
9
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8
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7
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3
2
2
2
Application
Immunohistochemistry (IHC)
681
577
333
323
299
291
229
169
100
97
84
21
17
6
6
5
5
5
3
3
3
2
2
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine1221/1222 (N-L-YP-YP -W).
Specificity HER2 (phospho-Tyr1221/Tyr1222) antibody detects endogenous levels of HER2 only when phosphorylated at tyrosine 1221/1222.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name HER2 (ERBB2 Antibody Abstract)
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Marone, Hess, Dankort, Muller, Hynes, Badache: "Memo mediates ErbB2-driven cell motility." in: Nature cell biology, Vol. 6, Issue 6, pp. 515-22, 2004 (PubMed).

Ren, Schaefer: "ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38486-93, 2002 (PubMed).