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HER2 antibody (V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian)) (pTyr1221)

Details for Product anti-ERBB2 Antibody No. ABIN966274, Supplier: Log in to see
Antigen
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • MLN 19
  • NEU
  • NGL
  • TKR1
  • Erbb-2
  • Neu
  • c-erbB2
  • c-neu
  • mKIAA3023
Alternatives
anti-Human HER2 antibody for Western Blotting
Epitope
pTyr1221, pTyr1222
116
82
63
54
53
53
51
44
36
32
32
29
21
20
20
20
20
19
19
19
19
19
19
18
18
18
15
14
14
14
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13
12
10
10
9
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8
8
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7
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7
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
1148
410
237
25
12
4
3
3
3
3
2
2
1
1
1
Host
Rabbit
940
350
19
18
5
5
Conjugate
This HER2 antibody is un-conjugated
66
61
52
45
45
41
11
9
9
8
8
8
8
8
8
2
2
1
Application
Immunohistochemistry (IHC)
624
513
323
318
215
182
133
112
93
45
21
17
12
6
6
5
5
5
3
3
2
2
1
1
1
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine1221/1222 (N-L-YP-YP -W).
Specificity HER2 (phospho-Tyr1221/Tyr1222) antibody detects endogenous levels of HER2 only when phosphorylated at tyrosine 1221/1222.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name HER2 (ERBB2 Antibody Abstract)
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Marone, Hess, Dankort et al.: "Memo mediates ErbB2-driven cell motility." in: Nature cell biology, Vol. 6, Issue 6, pp. 515-22, 2004 (PubMed).

Ren, Schaefer: "ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38486-93, 2002 (PubMed).