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V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (pTyr877) antibody

Antigen

V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2)
Synonyms Neu, HER2, HER-2, c-neu, Erbb-2, c-erbB2, mKIAA3023, NEU, NGL, TKR1, CD340, HER-2/neu
Binding Site
Alternatives

pTyr877
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
3 references available
Catalog no. ABIN966276
Quantity 100ug  (100ug/100ul.)  (Variants)
Price 385.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name HER2
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine 877 (T-E-YP-H-A).
Specificity HER2 (phospho-Tyr877) antibody detects endogenous levels of HER2 only when phosphorylated at tyrosine 877.

Application Details
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Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Qian, LeVea, Freeman et al.: "Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 4, pp. 1500-4, 1994 (PubMed).

Muthuswamy, Gilman, Brugge: "Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers." in: Molecular and cellular biology, Vol. 19, Issue 10, pp. 6845-57, 2000 (PubMed).

Dittadi, Gion: "More about: prognostic importance of low c-erbB2 expression in breast tumors." in: Journal of the National Cancer Institute, Vol. 92, Issue 17, pp. 1443-4, 2000 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2)", type "Antibodies"
Hosts Rabbit (359), Mouse (151), Chicken (10), Rat (7), Sheep (4), Goat (1)
Reactivities Human (509), Mouse (Murine) (199), Rat (Rattus) (181), Dog (Canine) (80), Horse (Equine) (72), Cow (Bovine) (37), Pig (Porcine) (36), Chicken (19), Guinea Pig (18), Sheep (Ovine) (18), Monkey (5), Cat (Feline) (1)
Applications Western Blotting (WB) (288), Immunofluorescence (IF) (192), ELISA (156), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (138), Immunohistochemistry (IHC) (128), Immunoprecipitation (IP) (96), Flow Cytometry (FACS) (29), Dot Blot (DB) (27), Immunocytochemistry (ICC) (26), Immunohistochemistry (Fixed) (IHC (fx)) (23), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (23), Immunohistochemistry (Frozen Sections) (IHC (fro)) (15), Electrophoretic Mobility-Shift Assay (EMSA) (11), Immunoelectron Microscopy (IEM) (6), Enzyme Immunoassay (EIA) (5), Functional Studies (Func) (4), Cellular Assay (CA) (1), Dot Blot (Dot) (1), Immunoassay (IA) (1), Immunostaining (ISt) (1), Radioimmunoassay (RIA) (1)
Conjugates Biotin (21), FITC (7), Alexa Fluor 350 (6), Alexa Fluor 488 (6), Alexa Fluor 555 (6), Alexa Fluor 647 (6), Cy3 (6), Cy5 (6), Cy5.5 (6), Cy7 (6), Gold (6), HRP (6), PE (6), PE,Cy3 (6), PE,Cy5 (6), PE,Cy5.5 (6), PE,Cy7 (6)
Epitopes pTyr1248 (41), C-Term (38), pTyr877 (35), pTyr1112 (24), pTyr1221,pTyr1222 (19), Extracellular Domain (18), pTyr686 (18), Internal Region (11), Tyr1248 (9), AA 750-987 (6), Cytoplasmic Domain (6), pTyr1221, pTyr1222 (6), N-Term (5), pThr686 (5), pTyr1222,pTyr1221 (5), AA 153-433 (3), pSer1113 (3), pTyr1112,C-Term (3), pTyr1139 (3), AA 1240-1260 (2), AA 1243-1255 (2), Tyr1221,Tyr1222 (2), Tyr877 (2), pSer1051 (2), AA 1238-1255 (1), AA 1242-1255,C-Term (1), AA 146-195 (1), AA 23-419 (1), AA 23-652 (1), AA 860-880 (1), AA 968-1020 (1), C-Term,AA 1008-1038 (1), C-Term,AA 1035-1064 (1), C-Term,AA 1039-1069 (1), C-Term,AA 1069-1098 (1), C-Term,AA 1092-1121 (1), C-Term,AA 1097-1127 (1), C-Term,AA 1112-1142 (1), C-Term,AA 1125-1154 (1), C-Term,AA 1136-1166 (1), C-Term,AA 1153-1183 (1), C-Term,AA 1158-1188 (1), C-Term,AA 1182-1211 (1), Internal Region,AA 530-559 (1), Internal Region,AA 714-743 (1), Internal Region,AA 862-891 (1), Internal Region,AA 984-1013 (1), Internal Region,AA 985-1014 (1), Ser1112 (1), Ser877 (1), Tyr1196 (1), Tyr1221, Tyr1222 (1), Tyr1222 (1), pSer1050 (1), pSer1054 (1), pSer1083 (1), pSer1107 (1), pSer1114 (1), pSer1151 (1), pSer1174 (1), pSer728 (1), pSer998 (1), pSer999 (1), pThr1166 (1), pThr1168 (1), pThr1172 (1), pThr1221, pThr1222 (1), pThr701 (1), pTyr1005 (1), pTyr1127 (1), pTyr1129 (1), pTyr1140 (1), pTyr1196 (1), pTyr1197 (1), pTyr1221 (1), pTyr1222 (1), pTyr1223 (1)