ErbB2/Her2 antibody

Catalog No. ABIN966278

Product Details anti-ErbB2/Her2 Antibody

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ErbB2/Her2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Specificity: HER2 (Ab-1248) antibody detects endogenous levels of total HER2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine 1248 (P-E-YP-L-G).

Application Details

Application Notes: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-ErbB2/Her2 antibody (ABIN966278)

Ramsauer, Carraway, Salas, Carraway: "Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30142-7, (2003) (PubMed).

Jepson, Komatsu, Haq, Arango, Huang, Carraway, Carraway et al.: "Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein ..." in: Oncogene, Vol. 21, Issue 49, pp. 7524-32, (2002) (PubMed).

Ren, Schaefer: "ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38486-93, (2002) (PubMed).

Eppenberger-Castori, Kueng, Benz, Caduff, Varga, Bannwart, Fink, Dieterich, Hohl, Müller, Paris, Schoumacher, Eppenberger: "Prognostic and predictive significance of ErbB-2 breast tumor levels measured by enzyme immunoassay." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 19, Issue 3, pp. 645-56, (2001) (PubMed).

Target Details for ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Alternative Name: HER2 (ErbB2/Her2 Products)

Synonyms: CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, Erbb-2 antibody, Neu antibody, c-erbB2 antibody, c-neu antibody, mKIAA3023 antibody, wu:fv70f10 antibody, zgc:63601 antibody, erb2 antibody, erb-b2 receptor tyrosine kinase 2 antibody, ERBB2 antibody, Erbb2 antibody, erbb2 antibody

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development