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HSP27 antibody

HSPB1 Reactivity: Human, Rat WB, IHC, ELISA, IF, FACS Host: Mouse Monoclonal 5D7 unconjugated
Catalog No. ABIN966308
  • Target See all HSP27 (HSPB1) Antibodies
    HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))
    Reactivity
    • 300
    • 104
    • 90
    • 24
    • 14
    • 14
    • 13
    • 12
    • 11
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Rat
    Host
    • 238
    • 66
    Mouse
    Clonality
    • 207
    • 96
    Monoclonal
    Conjugate
    • 138
    • 23
    • 17
    • 13
    • 12
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HSP27 antibody is un-conjugated
    Application
    • 257
    • 104
    • 104
    • 95
    • 70
    • 50
    • 49
    • 46
    • 41
    • 40
    • 16
    • 12
    • 10
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)
    Purification
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of human HSP27 expressed in E. Coli.
    Clone
    5D7
    Isotype
    IgG1
    Top Product
    Discover our top product HSPB1 Primary Antibody
  • Application Notes
    Western Bloting: 1/500 - 1/2000.
    Immunohistochemistry: 1/200 - 1/1000.
    Immunofluorescence: 1/200 - 1/1000.
    Flow cytometry: 1/200 - 1/400.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
  • Langer, Ott, Specht, Becker, Lordick, Burian, Herrmann, Schrattenholz, Cahill, Schwaiger, Hofler, Wester: "Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 24, pp. 8279-87, (2008) (PubMed).

    Wu, Liu, Zhang, Huang, Shen, Zhang, Jiang, Luo, Yin: "HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination." in: Cellular signalling, Vol. 21, Issue 1, pp. 143-50, (2008) (PubMed).

  • Target
    HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))
    Alternative Name
    HSP27 (HSPB1 Products)
    Synonyms
    CMT2F antibody, HMN2B antibody, HS.76067 antibody, HSP27 antibody, HSP28 antibody, Hsp25 antibody, SRP27 antibody, 27kDa antibody, Hsp27 antibody, cb153 antibody, cb660 antibody, hsp1 antibody, hsp25 antibody, hsp27 antibody, id:ibd2821 antibody, sb:cb660 antibody, zgc:103437 antibody, HSPB1 antibody, cmt2f antibody, hs.76067 antibody, hsp28 antibody, heat shock protein family B (small) member 1 antibody, heat shock protein 1 antibody, heat shock protein, alpha-crystallin-related, 1 antibody, heat shock protein family B (small) member 1 L homeolog antibody, HSPB1 antibody, Hspb1 antibody, hspb1 antibody, hspb1.L antibody
    Background
    The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN).
    Tissue specificity: Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle.
    Synonyms: CMT2F, HMN2B, HSP27, HSP28, Hsp25, SRP27, HS.76067, DKFZp586P1322, HSPB1
    Molecular Weight
    27kDa
    Gene ID
    3315
    Pathways
    MAPK Signaling, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, VEGF Signaling
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