IFNG antibody (Interferon gamma)

Details for Product anti-IFNG Antibody No. ABIN966336, Supplier: Log in to see
Antigen
  • IFNG2
  • IFN-g
  • Ifg
  • IFN-G
  • IFN-gamma
  • IFNG
  • IFG
  • IFI
  • interferon gamma
  • interferon gamma-like
  • interferon, gamma
  • Ifng
  • IFNG
  • LOC101337436
Alternatives
anti-Human IFNG antibody for Blocking Antibody
Reactivity
Human
775
278
144
71
47
42
32
32
31
24
23
22
22
18
17
13
13
13
10
10
10
10
9
6
5
4
2
1
1
1
Host
715
394
193
31
8
6
5
4
3
1
Clonality
Monoclonal
Conjugate
This IFNG antibody is un-conjugated
155
115
73
50
37
26
26
20
17
16
15
11
11
11
10
10
9
9
9
9
8
7
7
6
4
4
4
4
3
3
3
3
3
3
2
2
1
1
1
Application
ELISA, Western Blotting (WB)
708
655
516
183
133
125
92
86
85
65
49
45
38
31
23
20
13
12
11
9
7
7
6
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Options
Supplier
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Isotype IgG1
Specificity Ni-NTA purified recombinant human IFN-gamma expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name IFN-Y (IFNG Antibody Abstract)
Background Interferon-gamma (IFN-gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-gamma strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.
Gene ID 3458
Pathways Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy
Application Notes Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Background publications Takayanagi, Ogasawara, Hida, Chiba, Murata, Sato, Takaoka, Yokochi, Oda, Tanaka, Nakamura, Taniguchi: "T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma." in: Nature, Vol. 408, Issue 6812, pp. 600-5, 2000 (PubMed).

Product cited in: Tsubota, Fukagawa, Fujihara, Shimmura, Saito, Saito, Takeuchi: "Regulation of human leukocyte antigen expression in human conjunctival epithelium." in: Investigative ophthalmology & visual science, Vol. 40, Issue 1, pp. 28-34, 1999 (PubMed).