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IFNG antibody (Interferon gamma)

Details for Product anti-IFNG Antibody No. ABIN966336, Supplier: Log in to see
Antigen
  • IFNG2
  • IFN-g
  • Ifg
  • IFN-G
  • IFN-gamma
  • IFNG
  • IFG
  • IFI
Alternatives
anti-Human IFNG antibody for Enzyme Immunoassay
Reactivity
Human
613
264
145
57
35
25
20
20
13
13
12
11
9
9
9
9
7
6
6
6
6
6
5
2
1
1
1
Host
528
389
167
30
8
7
4
3
2
Clonality
Monoclonal
Conjugate
This IFNG antibody is un-conjugated
123
86
48
37
30
12
10
10
9
6
5
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
Application
ELISA, Western Blotting (WB)
624
551
350
124
117
115
70
60
48
40
38
38
37
32
29
17
14
9
9
8
7
7
7
4
4
4
3
2
2
2
2
2
1
1
1
1
1
1
1
Supplier
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Isotype IgG1
Specificity Ni-NTA purified recombinant human IFN-gamma expressed in E. Coli strain BL21 (DE3)
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name IFN-Y (IFNG Antibody Abstract)
Background Interferon-gamma (IFN-gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-gamma strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.
Gene ID 3458
Pathways Interferon-gamma Pathway
Application Notes Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Tsubota, Fukagawa, Fujihara et al.: "Regulation of human leukocyte antigen expression in human conjunctival epithelium." in: Investigative ophthalmology & visual science, Vol. 40, Issue 1, pp. 28-34, 1999 (PubMed).

Background publications Takayanagi, Ogasawara, Hida et al.: "T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma." in: Nature, Vol. 408, Issue 6812, pp. 600-5, 2000 (PubMed).