IGF1 antibody (Insulin-Like Growth Factor 1) (AA 80-96)

Details for Product anti-IGF1 Antibody No. ABIN966342, Supplier: Log in to see
Antigen
  • IGF-I
  • IGF1A
  • IGFI
  • C730016P09Rik
  • Igf-1
  • Igf-I
  • Npt2B
  • IGF-1
  • IGFIA
  • IGF-IB
  • igf1
  • IGF-1L
  • IGF-1a
  • IGF1
  • insulin-like growth factor 1 (somatomedin C)
  • insulin-like growth factor 1
  • insulin-like growth factor I
  • prepro IGF-I
  • IGF1
  • Igf1
  • LOC100136741
  • igf1
  • IGF-I
Alternatives
anti-Rat (Rattus) IGF1 antibody for Blocking Peptide
Epitope
AA 80-96
37
15
15
14
12
11
6
6
5
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
363
199
142
81
13
12
7
3
3
2
2
Host
213
164
39
15
7
2
2
1
Clonality
Polyclonal
Conjugate
This IGF1 antibody is un-conjugated
37
16
14
12
8
7
7
7
6
5
5
5
5
5
5
5
5
5
4
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
297
208
100
96
92
82
74
38
33
28
26
18
11
9
8
7
6
6
2
2
Options
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Immunogen A synthetic peptide corresponding to a sequence at the middle region of human IGF-1 (80-96 aa), different from the mouse and rat sequence by one amino acid.
Alternative Name IGF-1 (IGF1 Antibody Abstract)
Background Insulin-like growth factor 1 (IGF-1) also known as somatomedin C or mechano growth factor is a protein that in humans is encoded by the IGF1 gene. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.Justice et al. (1990) placed the mouse IGF1 gene on chromosome 10.
Research Area Diabetes, Metabolism, Growth Factors
Pathways RTK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation
Application Notes WB: The detection limit for IGF-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Höppener, de Pagter-Holthuizen, Geurts van Kessel, Jansen, Kittur, Antonarakis, Lips, Sussenbach: "The human gene encoding insulin-like growth factor I is located on chromosome 12." in: Human genetics, Vol. 69, Issue 2, pp. 157-60, 1985 (PubMed).

Jansen, van Schaik, Ricker, Bullock, Woods, Gabbay, Nussbaum, Sussenbach, Van den Brande: "Sequence of cDNA encoding human insulin-like growth factor I precursor." in: Nature, Vol. 306, Issue 5943, pp. 609-11, 1984 (PubMed).