Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) (pSer32), (pSer36) antibody

Details for Product No. ABIN966363
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Antigen
Synonyms AI462015, Nfkbi, IKBA, MAD-3, NFKBI, ECI-6/IKBA, RL/IF-1
Epitope
pSer32, pSer36
(54), (46), (38), (29), (25), (23), (22), (15), (15), (13), (13), (12), (7), (5), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(380), (185), (160), (6), (4), (4), (2), (2), (1)
Host
Rabbit
(338), (48), (7)
Conjugate
Un-conjugated
(16), (12), (10), (7), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Immunohistochemistry (IHC)
(281), (145), (132), (62), (54), (51), (40), (21), (17), (15), (9), (5), (4), (4), (1), (1), (1)
Pubmed 4 references available
Quantity 100 μg
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human IB- around the phosphorylation site of serine 32/36 (H-D-SP-G-L-D-SP -M-K).
Specificity IB- (phospho-Ser32/Ser36) antibody detects endogenous levels of IB- only when phosphorylated at serine 32/36.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name IkB-alpha (NFKBIA Antibody Abstract)
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Hirao, Kong, Matsuoka et al.: "DNA damage-induced activation of p53 by the checkpoint kinase Chk2." in: Science (New York, N.Y.), Vol. 287, Issue 5459, pp. 1824-7, 2000 (PubMed).

Shieh, Taya, Prives: "DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization." in: The EMBO journal, Vol. 18, Issue 7, pp. 1815-23, 1999 (PubMed).

Tibbetts, Brumbaugh, Williams et al.: "A role for ATR in the DNA damage-induced phosphorylation of p53." in: Genes & development, Vol. 13, Issue 2, pp. 152-7, 1999 (PubMed).

Honda, Tanaka, Yasuda: "Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53." in: FEBS letters, Vol. 420, Issue 1, pp. 25-7, 1998 (PubMed).

Validation Images
Catalog No. ABIN966363
398.75 $
Plus shipping costs $45.00
Quantity
Price
100 μg
398.75 $

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