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IL1A antibody (Interleukin 1 alpha) (C-Term)

Details for Product anti-IL1A Antibody No. ABIN966393, Supplier: Log in to see
Antigen
  • Il-1
  • Il-1a
  • IL-1 alpha
  • IL-1A
  • IL1
  • IL1-ALPHA
  • IL1F1
  • IL-1alpha
  • L1A
Alternatives
anti-Mouse (Murine) IL1A antibody for Enzyme Immunoassay
Epitope
C-Term, AA 256-270
16
13
10
9
6
6
5
5
5
5
5
5
4
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
228
97
53
8
7
7
7
6
5
3
2
1
1
Host
221
110
34
10
7
7
3
3
2
Clonality
Polyclonal
Conjugate
This IL1A antibody is un-conjugated
66
29
14
13
8
8
2
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
267
255
61
51
34
32
21
20
20
18
16
10
9
5
4
3
1
1
1
1
1
1
1
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of mouse IL-1 (256-270 aa), identical to the related mouse and rat sequence.
Alternative Name IL-1a (IL1A Antibody Abstract)
Background Interleukin-1 alpha (IL-1) is a protein that in humans is encoded by the IL1A gene. The protein encoded by this gene is a cytokine of the interleukin-1 family. Interleukin-1 alpha possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. Silver et al. (1990) showed that the mouse Il1a and Il1b genes are contained in a genomic fragment of about 70 kb. Further studies suggested that Il1b lies 5-prime to Il1a, that the 2 genes are oriented in the same direction, and that they are separated by about 50 kb.
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Pathways NF-kappaB Signaling, TCR Signaling
Application Notes WB: The detection limit for IL-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Dinarello, Bunn: "Fever." in: Seminars in oncology, Vol. 24, Issue 3, pp. 288-98, 1997 (PubMed).

Bankers-Fulbright, Kalli, McKean: "Interleukin-1 signal transduction." in: Life sciences, Vol. 59, Issue 2, pp. 61-83, 1996 (PubMed).

Nicklin, Weith, Duff: "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes." in: Genomics, Vol. 19, Issue 2, pp. 382-4, 1994 (PubMed).

March, Mosley, Larsen et al.: "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs." in: Nature, Vol. 315, Issue 6021, pp. 641-7, 1985 (PubMed).