Interleukin 1 alpha (IL1A) (C-Term), (AA 256-270) antibody

Details for Product No. ABIN966393
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Antigen
Synonyms Il-1, Il-1a, IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1, IL-1alpha, L1A
Epitope
C-Term, AA 256-270
(8), (8), (5), (5), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(170), (102), (50), (16), (16), (14), (4), (4), (4), (4), (1), (1), (1)
Host
Please enquire
(175), (75), (17), (13), (5), (4), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(45), (23), (7), (7), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(190), (187), (55), (40), (36), (29), (27), (21), (21), (21), (9), (9), (3), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 100 µg
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Catalog No. ABIN966393
316.25 $
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of mouse IL-1 (256-270 aa), identical to the related mouse and rat sequence.
Alternative Name IL-1a
Background Interleukin-1 alpha (IL-1) is a protein that in humans is encoded by the IL1A gene. The protein encoded by this gene is a cytokine of the interleukin-1 family. Interleukin-1 alpha possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. Silver et al. (1990) showed that the mouse Il1a and Il1b genes are contained in a genomic fragment of about 70 kb. Further studies suggested that Il1b lies 5-prime to Il1a, that the 2 genes are oriented in the same direction, and that they are separated by about 50 kb.
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Application Notes WB: The detection limit for IL-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: March, Mosley, Larsen et al.: "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs." in: Nature, Vol. 315, Issue 6021, pp. 641-7, 1985 (PubMed).

Nicklin, Weith, Duff: "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes." in: Genomics, Vol. 19, Issue 2, pp. 382-4, 1994 (PubMed).

Bankers-Fulbright, Kalli, McKean: "Interleukin-1 signal transduction." in: Life sciences, Vol. 59, Issue 2, pp. 61-83, 1996 (PubMed).

Dinarello, Bunn: "Fever." in: Seminars in oncology, Vol. 24, Issue 3, pp. 288-98, 1997 (PubMed).

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