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Interleukin 1 alpha (IL1A) (C-Term,AA 256-270) antibody

Antigen

Interleukin 1 alpha (IL1A)
Synonyms IL1, IL-1A, IL1F1, IL1-ALPHA, Il-1a, IL-1 alpha, Il1a
Binding Site
Alternatives

C-Term,AA 256-270
Clonality Polyclonal
Host
Reactivity
Alternatives

Mouse (Murine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
4 references available
Catalog no. ABIN966393
Quantity 100myg
Price 316.25 $   Plus shipping costs $45.00
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Additional Information
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Alternative name IL-1a
Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of mouse IL-1 (256-270 aa), identical to the related mouse and rat sequence.
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Description Interleukin-1 alpha (IL-1) is a protein that in humans is encoded by the IL1A gene. The protein encoded by this gene is a cytokine of the interleukin-1 family. Interleukin-1 alpha possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. Silver et al. (1990) showed that the mouse Il1a and Il1b genes are contained in a genomic fragment of about 70 kb. Further studies suggested that Il1b lies 5-prime to Il1a, that the 2 genes are oriented in the same direction, and that they are separated by about 50 kb.

Application Details
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Application Notes WB: The detection limit for IL-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative 0.05mg Thiomersal, 0.05mg NaN3.
Storage At -20°C for one year. After reconstitution, at 4°C for one month.
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Restrictions For Research Use only

Publications
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Product March, Mosley, Larsen et al.: "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs." in: Nature, Vol. 315, Issue 6021, pp. 641-7, 1985 (PubMed).

Nicklin, Weith, Duff: "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes." in: Genomics, Vol. 19, Issue 2, pp. 382-4, 1994 (PubMed).

Bankers-Fulbright, Kalli, McKean: "Interleukin-1 signal transduction." in: Life sciences, Vol. 59, Issue 2, pp. 61-83, 1996 (PubMed).

Dinarello, Bunn: "Fever." in: Seminars in oncology, Vol. 24, Issue 3, pp. 288-98, 1997 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Interleukin 1 alpha (IL1A)", type "Antibodies"
Hosts Rabbit (129), Mouse (44), Goat (13), Hamster (8), Armenian Hamster (3), Guinea Pig (3), Sheep (1)
Reactivities Human (107), Mouse (Murine) (76), Rat (Rattus) (53), Dog (Canine) (22), Pig (Porcine) (21), Cow (Bovine) (20), Sheep (Ovine) (18), 8 hydroxy 2’ deoxyguanosine (3), Goat (3), Horse (Equine) (3), Rabbit (3), Wild boar (Sus scrofa) (3), Cat (Feline) (1), Chicken (1)
Applications ELISA (132), Western Blotting (WB) (119), Immunofluorescence (IF) (47), Immunohistochemistry (IHC) (40), Flow Cytometry (FACS) (22), Neutralization (Neut) (20), Functional Studies (Func) (16), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (16), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (9), Blocking Antibody (Inhibition) (6), Immunoprecipitation (IP) (5), Blocking Antibody (Inhibition) (3), Immunoelectron Microscopy (IEM) (3), ELISPOT (2), Immunohistochemistry (Fixed) (IHC (fx)) (2), Dot Blot (Dot) (1), Immunoassay (IA) (1), Immunocytochemistry (ICC) (1)
Conjugates Biotin (30), FITC (15), PE (6), HRP (4), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Cy3 (3), Cy5 (3), Cy5.5 (3), Cy7 (3), Gold (3), PE-Cy3 (2), PE-Cy5 (2), PE-Cy5.5 (2), PE-Cy7 (2), Un-conjugated (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RPE (1)
Epitopes AA 1-112 (1), Center (1), Cleavage Site (1), N-Term (1), Ser87 (1)