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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Interleukin 1 alpha (IL1A) (C-Term,AA 256-270) antibody
|Synonyms||IL1, IL-1A, IL1F1, IL1-ALPHA, Il-1a, IL-1 alpha, Il1a|
Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|4 references available|
|Price||316.25 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminal of mouse IL-1 (256-270 aa), identical to the related mouse and rat sequence.|
|Reconstitution||0.2ml of distilled water will yield a concentration of 500µg/ml.|
|Description||Interleukin-1 alpha (IL-1) is a protein that in humans is encoded by the IL1A gene. The protein encoded by this gene is a cytokine of the interleukin-1 family. Interleukin-1 alpha possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. Silver et al. (1990) showed that the mouse Il1a and Il1b genes are contained in a genomic fragment of about 70 kb. Further studies suggested that Il1b lies 5-prime to Il1a, that the 2 genes are oriented in the same direction, and that they are separated by about 50 kb.|
|Application Notes||WB: The detection limit for IL-1 is approximately 2.5ng/lane under non-reducing and reducing conditions.|
|Buffer||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4|
|Preservative||0.05mg Thiomersal, 0.05mg NaN3.|
|Storage||At -20°C for one year. After reconstitution, at 4°C for one month.|
|Research Area||Cytokines, Immunology, Virology, Inflammation, Cancer|
|Restrictions||For Research Use only|
March, Mosley, Larsen et al.: "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs." in: Nature, Vol. 315, Issue 6021, pp. 641-7, 1985 (PubMed).
Nicklin, Weith, Duff: "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes." in: Genomics, Vol. 19, Issue 2, pp. 382-4, 1994 (PubMed).
Bankers-Fulbright, Kalli, McKean: "Interleukin-1 signal transduction." in: Life sciences, Vol. 59, Issue 2, pp. 61-83, 1996 (PubMed).
Dinarello, Bunn: "Fever." in: Seminars in oncology, Vol. 24, Issue 3, pp. 288-98, 1997 (PubMed).