Interleukin 6 antibody (IL6) (C-Term)

Details for Product anti-IL6 Antibody No. ABIN966395, Supplier: Log in to see
Antigen
  • Il-6
  • ILg6
  • Ifnb2
  • BSF2
  • HGF
  • HSF
  • IFNB2
  • IL-6
  • CHIL-6
  • il6
  • interleukin 6
  • interleukin 6 (interferon, beta 2)
  • interleukin-6
  • Il6
  • IL6
  • il-6
Alternatives
anti-Human Interleukin 6 antibody for Immunoprecipitation
Epitope
C-Term
66
50
27
20
15
15
15
14
13
10
10
9
9
8
7
7
6
6
5
3
3
3
2
1
1
1
1
1
1
Reactivity
Rat (Rattus)
578
240
112
37
29
26
21
10
7
7
7
6
4
3
3
2
1
Host
Rabbit
382
298
202
38
7
7
5
Clonality
Polyclonal
Conjugate
This Interleukin 6 antibody is un-conjugated
106
40
26
23
15
13
13
11
11
9
9
9
7
7
6
5
5
5
5
5
4
4
4
3
3
3
3
3
3
2
2
2
2
Application
Western Blotting (WB)
590
538
224
153
125
97
70
66
59
48
41
38
19
17
15
13
12
8
8
5
4
4
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
Options
Supplier
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of rat IL6, different from the related mouse sequence by two amino acids.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Interleukin-6 ( IL6) detection. Tested with WB in Mouse, Rat.
Alternative Name Interleukin-6(IL-6) (IL6 Antibody Abstract)
Background Interleukin-6 (IL-6) is a protein that in humans is encoded by the IL6 gene. IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is one of the most important mediators of fever and of the acute phase response. IL-6 is also essential for hybridoma growth and is found in many supplemental cloning media such as briclone. Bowcock et al. (1988) assigned the IL6 gene to chromosome 7p21. By in situ hybridization and Southern blot analysis of mouse-human hybrid cell lines, Sutherland et al. (1988) mapped the IL6 gene to chromosome 7p15.
Pathways Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Ferguson-Smith, Chen, Newman, May, Sehgal, Ruddle: "Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21." in: Genomics, Vol. 2, Issue 3, pp. 203-8, 1988 (PubMed).

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