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Interleukin 6 antibody (IL6) (C-Term)

Details for Product anti-IL6 Antibody No. ABIN966395, Supplier: Log in to see
Antigen
  • Il-6
  • ILg6
  • Ifnb2
  • BSF2
  • HGF
  • HSF
  • IFNB2
  • IL-6
  • CHIL-6
  • il6
  • interleukin 6
  • interleukin 6 (interferon, beta 2)
  • interleukin-6
  • Il6
  • IL6
  • il-6
Alternatives
anti-Rat (Rattus) Interleukin 6 antibody for Enzyme Immunoassay
Epitope
C-Term
60
43
21
20
15
15
15
14
13
10
10
9
9
7
7
7
6
6
5
3
3
3
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
546
231
111
37
29
21
17
7
7
7
6
6
4
3
3
1
1
Host
Rabbit
361
271
198
37
7
7
3
Clonality
Polyclonal
Conjugate
This Interleukin 6 antibody is un-conjugated
101
38
24
22
11
11
10
8
8
7
6
6
6
6
5
5
5
5
5
5
4
4
4
3
3
3
3
3
3
2
2
2
2
Application
Western Blotting (WB)
575
522
192
144
122
90
64
62
53
43
41
38
19
17
13
13
12
8
5
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
Options
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of rat IL6, different from the related mouse sequence by two amino acids.< br/>Immunogen was affinity purified.
Isotype IgG
Cross-Reactivity Mouse (Murine)
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Interleukin-6 ( IL6) detection. Tested with WB in Mouse, Rat.
Alternative Name Interleukin-6(IL-6) (IL6 Antibody Abstract)
Background Interleukin-6 (IL-6) is a protein that in humans is encoded by the IL6 gene. IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is one of the most important mediators of fever and of the acute phase response. IL-6 is also essential for hybridoma growth and is found in many supplemental cloning media such as briclone. Bowcock et al. (1988) assigned the IL6 gene to chromosome 7p21. By in situ hybridization and Southern blot analysis of mouse-human hybrid cell lines, Sutherland et al. (1988) mapped the IL6 gene to chromosome 7p15.
Pathways Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Product cited in: Ferguson-Smith, Chen, Newman, May, Sehgal, Ruddle: "Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21." in: Genomics, Vol. 2, Issue 3, pp. 203-8, 1988 (PubMed).