Inhibin alpha antibody

Catalog No. ABIN966402

Product Details anti-Inhibin alpha Antibody

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This Inhibin alpha antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: Ni-NTA purified truncated recombinant INHA expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 1,000- 1: 2,000
ELISA: Propose dilution 1: 10,000 Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Storage: -20 °C

References for anti-Inhibin alpha antibody (ABIN966402)

Knight: "Roles of inhibins, activins, and follistatin in the female reproductive system." in: Frontiers in neuroendocrinology, Vol. 17, Issue 4, pp. 476-509, (1997) (PubMed).

Fahy, Wilson, Beard, Groome, Knight et al.: "Changes in inhibin-A (alpha-beta A dimer) and total alpha inhibin in the peripheral circulation and ovaries of rats after gonadotrophin-induced follicular development and during the normal oestrous ..." in: The Journal of endocrinology, Vol. 147, Issue 2, pp. 271-83, (1996) (PubMed).

Lambert-Messerlian, Crowley, Schneyer: "Extragonadal alpha-inhibin precursor proteins circulate in human male serum." in: The Journal of clinical endocrinology and metabolism, Vol. 80, Issue 10, pp. 3043-9, (1995) (PubMed).

Mayo, Cerelli, Spiess, Rivier, Rosenfeld, Evans, Vale: "Inhibin A-subunit cDNAs from porcine ovary and human placenta." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 16, pp. 5849-53, (1986) (PubMed).

Target Details for Inhibin alpha

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Alternative Name: INHA (INHA Products)

Synonyms: si:dkey-91f15.2 antibody, INHA antibody, MGC108500 antibody, AW555078 antibody, inhibin, alpha antibody, inhibin alpha subunit antibody, inhibin alpha antibody, inhibin alpha L homeolog antibody, inha antibody, INHA antibody, inha.L antibody, Inha antibody

Background: INHA(A-inhibin subunit precursor, inhibin alpha subunit ),also called inhibin(alpha) ,which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.

Gene ID: 3623

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion