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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Insulin Receptor Substrate 1 (IRS1) (pSer307) antibody
|Synonyms||HIRS-1, G972R, IRS-1, IRS1IRM, irs1, MGC75645, IRS1|
Human, Mouse (Murine), Rat (Rattus)
Alternatives Immunohistochemistry (IHC)
|3 references available|
|Quantity||100ug (100ug/100ul.) (Variants)|
|Price||385.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||The antiserum was produced against synthesized phosphopeptide derived from human IRS1 around the phosphorylation site of serine 307 (T-E-SP-I-T).|
|Specificity||IRS-1 (phospho-Ser307) antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 307.|
|Application Notes||IHC: 1:50-1:100.|
|Purification||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.|
|Buffer||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol|
|Preservative||0.02% Sodium Azide|
|Storage||Store at -20°C/1 year.|
|Restrictions||For Research Use only|
Steppan, Wang, Whiteman et al.: "Activation of SOCS-3 by resistin." in: Molecular and cellular biology, Vol. 25, Issue 4, pp. 1569-75, 2005 (PubMed).
Tuncman, Hirosumi, Solinas et al.: "Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 28, pp. 10741-6, 2006 (PubMed).
Shoelson, Lee, Goldfine: "Inflammation and insulin resistance." in: The Journal of clinical investigation, Vol. 116, Issue 7, pp. 1793-801, 2006 (PubMed).