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Insulin Receptor Substrate 1 (IRS1) (pSer636) antibody

Details for Product No. ABIN966414, Supplier: Log in to see
Antigen
  • irs1
  • irsu
  • IRS1
  • HIRS-1
  • G972R
  • IRS-1
  • IRS1IRM
  • irs-1
  • irs1-a
  • insulin receptor substrate 2
  • insulin receptor substrate 1
  • irs2
  • IRS1
  • Irs1
  • irs1
Alternatives
anti-Human Insulin Receptor Substrate 1 antibody for Enzyme Immunoassay
Epitope
pSer636
59
51
47
46
28
25
22
19
17
17
17
16
15
15
15
15
15
12
10
9
8
6
6
5
5
5
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
565
456
433
19
16
6
5
4
4
1
1
Host
Rabbit
560
32
Conjugate
Un-conjugated
13
11
11
11
10
10
10
10
10
10
10
10
10
10
2
2
1
1
Application
Immunohistochemistry (IHC)
344
227
152
130
127
108
31
29
14
12
4
3
2
Options
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human IRS1 around the phosphorylation site of serine 636 (P-M-SP-P-K).
Specificity IRS-1 (phospho-Ser636) antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 636.
Alternative Name IRS-1 (IRS1 Antibody Abstract)
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis
Application Notes IHC: 1:50~1:100
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Tzatsos, Kandror: "Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 63-76, 2005 (PubMed).

Kadowaki: "Insights into insulin resistance and type 2 diabetes from knockout mouse models." in: The Journal of clinical investigation, Vol. 106, Issue 4, pp. 459-65, 2000 (PubMed).

Background publications Ozes, Akca, Mayo, Gustin, Maehama, Dixon, Donner: "A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4640-5, 2001 (PubMed).