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Insulin Receptor Substrate 1 (IRS1) (pSer636) antibody

Details for Product No. ABIN966414, Supplier: Login to see
Antigen
  • irs1
  • irsu
  • IRS1
  • HIRS-1
  • G972R
  • IRS-1
  • IRS1IRM
  • irs-1
  • irs1-a
Alternatives
anti-Human Insulin Receptor Substrate 1 antibody for Enzyme Immunoassay
Epitope
pSer636
55
50
47
46
24
24
23
21
16
16
15
14
14
13
13
13
13
13
9
9
8
8
6
5
5
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
536
353
336
10
9
5
1
1
Host
Rabbit
533
30
Conjugate
Un-conjugated
13
12
11
11
11
10
10
10
10
10
10
10
2
1
1
1
Application
Immunohistochemistry (IHC)
333
221
140
112
103
85
34
32
11
4
2
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human IRS1 around the phosphorylation site of serine 636 (P-M-SP-P-K).
Specificity IRS-1 (phospho-Ser636) antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 636.
Alternative Name IRS-1 (IRS1 Antibody Abstract)
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes IHC: 1:50~1:100
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Tzatsos, Kandror: "Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 63-76, 2005 (PubMed).

Kadowaki: "Insights into insulin resistance and type 2 diabetes from knockout mouse models." in: The Journal of clinical investigation, Vol. 106, Issue 4, pp. 459-65, 2000 (PubMed).

Background publications Ozes, Akca, Mayo et al.: "A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4640-5, 2001 (PubMed).