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Details for Product No. ABIN966415

Insulin Receptor Substrate 1 (IRS1) (pSer639) antibody

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Antigen
Synonyms HIRS-1, G972R, IRS-1, IRS1IRM, irs1, irsu, IRS1
Epitope
»Alternatives pSer639
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN966415
Quantity 100 µg
Price
385.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 7 Business Days
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 639 (P-K-SP-V-S).
Specificity IRS-1 (phospho-Ser639) antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 639.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Alternative Name IRS-1
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Storage -20 °C
Product cited in: Ozes, Akca, Mayo et al.: "A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4640-5, 2001 (PubMed).

Batty, Fleming, Downes: "Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells." in: The Biochemical journal, Vol. 379, Issue Pt 3, pp. 641-51, 2004 (PubMed).

Steppan, Wang, Whiteman et al.: "Activation of SOCS-3 by resistin." in: Molecular and cellular biology, Vol. 25, Issue 4, pp. 1569-75, 2005 (PubMed).

Tzatsos, Kandror: "Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 63-76, 2005 (PubMed).

Alternatives for antigen "Insulin Receptor Substrate 1 (IRS1)", type "Antibodies"
Hosts (454), (15)
Reactivities (439), (351), (335), (132), (121), (97), (77), (36), (1)
Applications (260), (162), (127), (120), (101), (67), (33), (24), (6), (4), (1)
Conjugates (13), (12), (12), (12), (12), (12), (12), (12), (12), (12), (12)
Epitopes (37), (36), (35), (34), (23), (17), (17), (16), (16), (13), (13), (12), (12), (12), (12), (12), (6), (6), (6), (4), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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