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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Insulin Receptor Substrate 1 (IRS1) (pSer639) antibody
|Synonyms||HIRS-1, G972R, IRS-1, IRS1IRM, irs1, MGC75645, IRS1|
Human, Mouse (Murine), Rat (Rattus)
Alternatives Immunohistochemistry (IHC)
|4 references available|
|Quantity||100ug (100ug/100ul.) (Variants)|
|Price||385.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||The antiserum was produced against synthesized phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 639 (P-K-SP-V-S).|
|Specificity||IRS-1 (phospho-Ser639) antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 639.|
|Application Notes||IHC: 1:50-1:100.|
|Purification||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.|
|Buffer||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol|
|Preservative||0.02% Sodium Azide|
|Storage||Store at -20°C/1 year.|
|Restrictions||For Research Use only|
Ozes, Akca, Mayo et al.: "A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4640-5, 2001 (PubMed).
Batty, Fleming, Downes: "Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells." in: The Biochemical journal, Vol. 379, Issue Pt 3, pp. 641-51, 2004 (PubMed).
Steppan, Wang, Whiteman et al.: "Activation of SOCS-3 by resistin." in: Molecular and cellular biology, Vol. 25, Issue 4, pp. 1569-75, 2005 (PubMed).
Tzatsos, Kandror: "Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 63-76, 2005 (PubMed).