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JAK2 antibody (Janus Kinase 2) (AA 745-955)

Details for Product anti-JAK2 Antibody No. ABIN966429, Supplier: Log in to see
Antigen
  • JAK2bCA
  • jak2
  • JTK10
  • THCYT3
  • AI504024
  • C81284
  • Fd17
  • JAK-2
  • Janus kinase 2b
  • Janus kinase 2
  • tyrosine-protein kinase JAK2-like
  • jak2b
  • JAK2
  • Jak2
  • LOC100051487
Alternatives
anti-Human JAK2 antibody for Western Blotting
Epitope
AA 745-955
46
29
19
17
15
12
11
11
9
8
8
7
5
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
256
166
153
8
7
6
6
2
1
1
1
Host
Mouse
247
20
5
Clonality (Clone)
Monoclonal ()
Conjugate
This JAK2 antibody is un-conjugated
9
6
6
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
181
122
103
27
26
26
16
11
9
9
3
3
Options
Supplier
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Immunogen Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
Clone 1C1
Isotype IgG1
Purification Ascitic fluid
Alternative Name JAK2 (JAK2 Antibody Abstract)
Background This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
Synonyms: JTK10, JAK2
Molecular Weight 130.6kDa
Gene ID 3717
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Hermanns, Radtke, Haan, Schmitz-Van de Leur, Tavernier, Heinrich, Behrmann: "Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6651-8, 2000 (PubMed).

Pollack, Kotenko, He, Izotova, Barnoski, Pestka: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, 1999 (PubMed).

Mol, de Rijke, Demacker, Stalenhoef: "Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment." in: Atherosclerosis, Vol. 129, Issue 2, pp. 169-76, 1997 (PubMed).