JAK2 antibody (Janus Kinase 2) (pTyr1007)

Details for Product anti-JAK2 Antibody No. ABIN966430, Supplier: Log in to see
Antigen
  • JAK2bCA
  • jak2
  • JTK10
  • THCYT3
  • AI504024
  • C81284
  • Fd17
  • JAK-2
  • Janus kinase 2b
  • Janus kinase 2
  • tyrosine-protein kinase JAK2-like
  • jak2b
  • JAK2
  • Jak2
  • LOC100051487
Alternatives
anti-Human JAK2 antibody for Western Blotting
Epitope
pTyr1007
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Conjugate
This JAK2 antibody is un-conjugated
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Application
Immunohistochemistry (IHC)
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Options
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human JAK2 around the phosphorylation site of tyrosine 1007 (K-E-YP-Y-K).
Specificity JAK2 (phospho-Tyr1007) antibody detects endogenous levels of JAK2 only when phosphorylated at tyrosine 1007.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name JAK2 (JAK2 Antibody Abstract)
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded protein response
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: James, Ugo, Le Couédic, Staerk, Delhommeau, Lacout, Garçon, Raslova, Berger, Bennaceur-Griscelli, Villeval, Constantinescu, Casadevall, Vainchenker: "A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera." in: Nature, Vol. 434, Issue 7037, pp. 1144-8, 2005 (PubMed).

Argetsinger, Kouadio, Steen, Stensballe, Jensen, Carter-Su: "Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4955-67, 2004 (PubMed).

Ungureanu, Saharinen, Junttila, Hilton, Silvennoinen: "Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3316-26, 2002 (PubMed).

Xie, Wang, Liu, Sun, Wilson, Smithgall, Arlinghaus: "Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation." in: Oncogene, Vol. 20, Issue 43, pp. 6188-95, 2001 (PubMed).

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