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Janus Kinase 2 (JAK2) (pTyr1007) antibody

Details for Product No. ABIN966430
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Antigen
Synonyms JAK2bCA, jak2, JTK10, THCYT3, AI504024, C81284, Fd17, JAK-2
Epitope
pTyr1007
(34), (28), (15), (13), (11), (10), (8), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(188), (156), (150), (38), (25), (24), (12), (2), (2), (1), (1)
Host
Rabbit
(190), (11), (2)
Conjugate
Un-conjugated
(7), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Application
Immunohistochemistry (IHC)
(131), (84), (82), (30), (30), (18), (15), (11), (4), (3), (2)
Pubmed 4 references available
Quantity 100 µg
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Catalog No. ABIN966430
385.00 $
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human JAK2 around the phosphorylation site of tyrosine 1007 (K-E-YP-Y-K).
Specificity JAK2 (phospho-Tyr1007) antibody detects endogenous levels of JAK2 only when phosphorylated at tyrosine 1007.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name JAK2
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Xie, Wang, Liu et al.: "Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation." in: Oncogene, Vol. 20, Issue 43, pp. 6188-95, 2001 (PubMed).

Ungureanu, Saharinen, Junttila et al.: "Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3316-26, 2002 (PubMed).

Argetsinger, Kouadio, Steen et al.: "Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4955-67, 2004 (PubMed).

James, Ugo, Le Couédic et al.: "A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera." in: Nature, Vol. 434, Issue 7037, pp. 1144-8, 2005 (PubMed).

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