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Janus Kinase 2 (JAK2) (pTyr1007) antibody

Antigen

Janus Kinase 2 (JAK2)
Synonyms JTK10, Fd17, C81284, AI504024, JAK2, DKFZp469G074
Binding Site
Alternatives

pTyr1007
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (IHC)
4 references available
Catalog no. ABIN966430
Quantity 100ug  (100ug/100ul.)  (Variants)
Price 385.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name JAK2
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human JAK2 around the phosphorylation site of tyrosine 1007 (K-E-YP-Y-K).
Specificity JAK2 (phospho-Tyr1007) antibody detects endogenous levels of JAK2 only when phosphorylated at tyrosine 1007.

Application Details
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Application Notes IHC: 1:50-1:100.
Concentration 100ug/100ul.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative 0.02% Sodium Azide
Storage Store at -20°C/1 year.
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Xie, Wang, Liu et al.: "Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation." in: Oncogene, Vol. 20, Issue 43, pp. 6188-95, 2001 (PubMed).

Ungureanu, Saharinen, Junttila et al.: "Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3316-26, 2002 (PubMed).

Argetsinger, Kouadio, Steen et al.: "Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4955-67, 2004 (PubMed).

James, Ugo, Le Couédic et al.: "A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera." in: Nature, Vol. 434, Issue 7037, pp. 1144-8, 2005 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Janus Kinase 2 (JAK2)", type "Antibodies"
Hosts Rabbit (130), Mouse (6), Goat (1)
Reactivities Human (126), Rat (Rattus) (113), Mouse (Murine) (102), Pig (Porcine) (56), Chicken (54), Zebrafish (36), Cow (Bovine) (18), Dog (Canine) (18), Chimpanzee (2), Horse (Equine) (2), Opossum (Didelphimorphia) (1), Primate (1)
Applications Western Blotting (WB) (63), ELISA (51), Immunofluorescence (IF) (48), Immunohistochemistry (IHC) (40), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (17), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (9), Immunoprecipitation (IP) (4), Immunocytochemistry (ICC) (3), Immunoelectron Microscopy (IEM) (3)
Conjugates Biotin (6), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Cy3 (3), Cy5 (3), Cy5.5 (3), Cy7 (3), FITC (3), Gold (3), HRP (3), PE (3), PE,Cy3 (3), PE,Cy5 (3), PE,Cy5.5 (3), PE,Cy7 (3)
Epitopes pTyr221 (22), pTyr1007,pTyr1008 (13), pTyr1007 (9), pTyr1008,pTyr1007 (5), C-Term (3), Internal Region (3), pTyr119,N-Term (3), pTyr570,Internal Region (3), pTyr931,C-Term (3), AA 745-955 (2), Tyr1007 (2), pTyr211 (2), Center (1), pTyr1007, pTyr1008 (1), pTyr570 (1), pTyr931 (1), pTyr972 (1)