JAK2 antibody (Janus Kinase 2) (pTyr221)

Details for Product anti-JAK2 Antibody No. ABIN966431, Supplier: Log in to see
Antigen
  • JAK2bCA
  • jak2
  • JTK10
  • THCYT3
  • AI504024
  • C81284
  • Fd17
  • JAK-2
  • Janus kinase 2b
  • Janus kinase 2
  • tyrosine-protein kinase JAK2-like
  • jak2b
  • JAK2
  • Jak2
  • LOC100051487
Alternatives
anti-Human JAK2 antibody for Immunofluorescence (fixed cells)
Epitope
pTyr221
46
27
19
16
15
13
11
10
10
9
8
7
7
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
264
160
148
8
6
6
6
2
1
1
Host
Rabbit
253
22
5
Conjugate
This JAK2 antibody is un-conjugated
11
8
6
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC)
185
119
103
28
27
27
20
15
12
9
7
3
2
Options
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human JAK2 around the phosphorylation site of tyrosine 221 (Q-D-YP-H-I).
Specificity JAK2 (phospho-Tyr221) antibody phosphorylated at tyrosine 221.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name JAK2 (JAK2 Antibody Abstract)
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Feener, Rosario, Dunn, Stancheva, Myers: "Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4968-78, 2004 (PubMed).

Argetsinger, Kouadio, Steen, Stensballe, Jensen, Carter-Su: "Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4955-67, 2004 (PubMed).