MAP2K1 antibody (Mitogen-Activated Protein Kinase Kinase 1) (C-Term)

Details for Product anti-MAP2K1 Antibody No. ABIN966512, Supplier: Log in to see
Antigen
  • Mek1
  • CFC3
  • MAPKK1
  • MEK1
  • MKK1
  • PRKMK1
  • MEKK1
  • Prkmk1
  • mek-2
  • si:ch211-242m18.2
  • wu:fj56a12
  • wu:fj61b01
  • zgc:56557
  • ATMEK1
  • F20B18.180
  • F20B18_180
  • MAP kinase/ ERK kinase 1
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE 1
  • NMAPKK
  • MEK
  • mitogen activated protein kinase kinase 1
  • mitogen-activated protein kinase kinase 1
  • Map2k1
  • MAP2K1
  • map2k1
  • MEK1
Alternatives
anti-Rat (Rattus) MAP2K1 antibody for BioImaging
Epitope
C-Term, AA 353-367
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35
33
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32
27
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19
15
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15
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2
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1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
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1
Reactivity
Human, Rat (Rattus)
633
427
374
108
80
45
30
26
22
21
10
8
5
5
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4
4
2
1
1
Host
504
129
5
4
2
1
Clonality
Polyclonal
Conjugate
This MAP2K1 antibody is un-conjugated
16
15
15
11
9
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8
8
6
6
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6
6
2
2
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
495
197
161
132
121
78
27
22
15
10
9
6
6
6
2
2
2
1
1
1
1
Options
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Immunogen A synthetic peptide corresponding to a sequence at the C-terminal of human MAP2K1 (353-367aa), identical to the related mouse and rat sequence.
Alternative Name MAP2K1 (MAP2K1 Antibody Abstract)
Background Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon activation by a wide variety of extra- and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. Rampoldi et al. (1997) localized the MAP2K1 gene to 15q22.1-q22.33.
Research Area Kinases/Phosphatases, Phospho-specific antibodies
Pathways MAPK Signaling, RTK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Product cited in: Rampoldi, Zimbello, Bortoluzzi, Tiso, Valle, Lanfranchi, Danieli: "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5." in: Cytogenetics and cell genetics, Vol. 78, Issue 3-4, pp. 301-3, 1998 (PubMed).

Zheng, Guan: "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2." in: The Journal of biological chemistry, Vol. 268, Issue 15, pp. 11435-9, 1993 (PubMed).