Microtubule-Associated Protein 4 (MAP4) (Isoform 4), (pSer1046) antibody

Details for Product No. ABIN966517
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Antigen
Synonyms XMAP4, mtap4, AA407148, MAP-4, Mtap-4, Mtap4
Epitope
Isoform 4, pSer1046
(14), (12), (12), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(74), (60), (59), (48), (48), (48), (24)
Host
Rabbit
(71), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Please inquire
(40), (26), (16), (14), (13), (9), (2), (2)
Pubmed 6 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN966517
452.38 $
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human MAP4 (microtubule-associated protein 4 isoform 4)
Alternative Name MAP4
Background MAP4 (microtubule-associated protein 4 isoform 4) is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms: DKFZp779A1753, MGC8617
Restrictions For Research Use only
Product cited in: West, Tenbarge, Olmsted: "A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences." in: The Journal of biological chemistry, Vol. 266, Issue 32, pp. 21886-96, 1991 (PubMed).

Chapin, Lue, Yu et al.: "Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains." in: Biochemistry, Vol. 34, Issue 7, pp. 2289-301, 1995 (PubMed).

Ookata, Hisanaga, Bulinski et al.: "Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics." in: The Journal of cell biology, Vol. 128, Issue 5, pp. 849-62, 1995 (PubMed).

Beausoleil, Villén, Gerber et al.: "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." in: Nature biotechnology, Vol. 24, Issue 10, pp. 1285-92, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Wu, Ma, Brown et al.: "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening." in: Proteomics, Vol. 7, Issue 11, pp. 1775-85, 2007 (PubMed).

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