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MAP4 antibody (Microtubule-Associated Protein 4) (Isoform 4)

Details for Product anti-MAP4 Antibody No. ABIN966517, Supplier: Log in to see
Antigen
  • AA407148
  • MAP-4
  • Mtap-4
  • Mtap4
  • mtap4
  • XMAP4
Epitope
Isoform 4, pSer1046
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
50
30
30
Host
Rabbit
48
4
Clonality
Polyclonal
Conjugate
This MAP4 antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
25
19
16
14
10
10
6
2
2
1
Supplier
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Supplier Product No.
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human MAP4 (microtubule-associated protein 4 isoform 4)
Alternative Name MAP4 (MAP4 Antibody Abstract)
Background MAP4 (microtubule-associated protein 4 isoform 4) is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms: DKFZp779A1753, MGC8617
Pathways p53 Signaling, Microtubule Dynamics
Restrictions For Research Use only
Product cited in: Wu, Ma, Brown, Geisler, Li, Tzeng, Jia, Jurisica, Li: "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening." in: Proteomics, Vol. 7, Issue 11, pp. 1775-85, 2007 (PubMed).

Beausoleil, Villén, Gerber, Rush, Gygi: "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." in: Nature biotechnology, Vol. 24, Issue 10, pp. 1285-92, 2006 (PubMed).

Ookata, Hisanaga, Bulinski, Murofushi, Aizawa, Itoh, Hotani, Okumura, Tachibana, Kishimoto: "Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics." in: The Journal of cell biology, Vol. 128, Issue 5, pp. 849-62, 1995 (PubMed).

Chapin, Lue, Yu, Bulinski: "Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains." in: Biochemistry, Vol. 34, Issue 7, pp. 2289-301, 1995 (PubMed).

West, Tenbarge, Olmsted: "A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences." in: The Journal of biological chemistry, Vol. 266, Issue 32, pp. 21886-96, 1991 (PubMed).

Background publications Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).