MAPK10 antibody

Catalog No. ABIN966522

Product Details anti-MAPK10 Antibody

Target: MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This MAPK10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: Ni-NTA purified truncated recombinant MAPK10 expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 500- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Storage: -20 °C

References for anti-MAPK10 antibody (ABIN966522)

Irving, Bamford: "Role of mitogen- and stress-activated kinases in ischemic injury." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 22, Issue 6, pp. 631-47, (2002) (PubMed).

Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, (2000) (PubMed).

Kuan, Yang, Samanta Roy, Davis, Rakic, Flavell: "The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development." in: Neuron, Vol. 22, Issue 4, pp. 667-76, (1999) (PubMed).

Gupta, Barrett, Whitmarsh, Cavanagh, Sluss, Dérijard, Davis: "Selective interaction of JNK protein kinase isoforms with transcription factors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2760-70, (1996) (PubMed).

Martin, Mohit, Miller: "Developmental expression in the mouse nervous system of the p493F12 SAP kinase." in: Brain research. Molecular brain research, Vol. 35, Issue 1-2, pp. 47-57, (1996) (PubMed).

Forsgren, Moravec, Moravec: "Catecholamine-synthesizing enzymes and neuropeptides in rat heart epicardial ganglia; an immunohistochemical study." in: The Histochemical journal, Vol. 22, Issue 12, pp. 667-76, (1991) (PubMed).

Target Details for MAPK10

Target: MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Alternative Name: MAPK10 (MAPK10 Products)

Synonyms: MAPK10 antibody, zgc:123234 antibody, DKFZp459H0638 antibody, Jnk3 antibody, SAPKC antibody, SAPb antibody, Serk2 antibody, JNK3 antibody, JNK3A antibody, PRKM10 antibody, SAPK1b antibody, p493F12 antibody, p54bSAPK antibody, C230008H04Rik antibody, JNK3B1 antibody, JNK3B2 antibody, SAPK(beta) antibody, ATMPK10 antibody, MAP kinase 10 antibody, mitogen-activated protein kinase 8 S homeolog antibody, mitogen-activated protein kinase 10 antibody, mitogen activated protein kinase 10 antibody, MAP kinase 10 antibody, mapk8.S antibody, MAPK10 antibody, mapk10 antibody, Mapk10 antibody, MPK10 antibody

Background: MAPK10 (mitogen-activated protein kinase 10 ), also called JNK3, which is located on chromosome 4q22.1q23, JNK is an important contributor to stress-induced apoptosis, its isoforms (JNK1, JNK2, and JNK3) have distinct roles in cerebral ischemia. JNK1 is the major isoformresponsible for the high level of basal JNK activity in the brain. In contrast, targeted deletion of Jnk3 not only reduces the stress-induced JNK activity, but also protects mice from brain injury after cerebral ischemiahypoxia. The downstream mechanism of JNK3-mediated apoptosis include the induction of Bim and Fas and the mitochondrial release of cytochrome c. which suggest that JNK3 is a potential target for neuroprotection therapies in stroke. JNK3 is crucial for neuronal apoptosis (stress-induced) and selectively expressed in the nervous system and heart.

Gene ID: 5602

Pathways: MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades