Mitogen-Activated Protein Kinase 11 (MAPK11) (pThr180,pTyr182) antibody

Antigen: Mitogen-Activated Protein Kinase 11 (MAPK11)

Synonyms: P38B, SAPK2, p38-2, PRKM11, SAPK2B, p38Beta, P38BETA2, P38b, Sapk2, Prkm11, Sapk2b, p38beta, p38beta2, DKFZp586C1322, MAPK11, MGC139500, MGC187942, ATMPK11, F22L4.10, F22L4_10, MAP kinase 11, MPK11, p38b, sapk2, prkm11, sapk2b

Binding Site: pThr180,pTyr182

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human, Mouse (Murine)

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN966524

Additional Information

Alternative name: MAPK11

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle amino acid residues of human MAPK11 (Mitogen-activated protein kinase 11)

Description: MAPK11 (Mitogen-activated protein kinase 11) is involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. MAPK11 (Mitogen-activated protein kinase 11) phosphorylates preferentially transcription factor ATF2. MAPK11 (Mitogen-activated protein kinase 11) is activated by phosphorylation on threonine and tyrosine by MKK6. MAPK11 is inhibited by pyridinyl-imidazole related compounds. Highest levels of MAPK11 expression is in the brain and heart. MAPK11 is also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. MAPK11 is dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme. MAPK11 belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family and MAP kinase subfamily. MAPK11 contains 1 protein kinase domain.
Synonyms: PRKM11, SAPK2 (Stress-activated protein kinase 2), p38-2 (Mitogen-activated protein kinase p38 beta), p38b (MAP kinase p38 beta)

Synonyms: P38B, SAPK2, p38-2, PRKM11, SAPK2B, p38Beta, P38BETA2, P38b, Sapk2, Prkm11, Sapk2b, p38beta, p38beta2, DKFZp586C1322, MAPK11, MGC139500, MGC187942, ATMPK11, F22L4.10, F22L4_10, MAP kinase 11, MPK11, p38b, sapk2, prkm11, sapk2b

Application Details

Research Area: Signaling

Restrictions: For Research Use only

Publications

Product: Jiang, Chen, Li et al.: "Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)." in: The Journal of biological chemistry, Vol. 271, Issue 30, pp. 17920-6, 1996 (PubMed).

Kumar, McDonnell, Gum et al.: "Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles." in: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 533-8, 1997 (PubMed).

Stein, Yang, Young et al.: "p38-2, a novel mitogen-activated protein kinase with distinct properties." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19509-17, 1997 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).