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Mitogen-Activated Protein Kinase 11 (MAPK11) (pThr180,pTyr182) antibody
Human, Mouse (Murine)
Alternatives Immunohistochemistry (IHC)
|4 references available|
|Price||452.38 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 5 to 7 Business Days|
|Immunogen||Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle amino acid residues of human MAPK11 (Mitogen-activated protein kinase 11)|
MAPK11 (Mitogen-activated protein kinase 11) is involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. MAPK11 (Mitogen-activated protein kinase 11) phosphorylates preferentially transcription factor ATF2. MAPK11 (Mitogen-activated protein kinase 11) is activated by phosphorylation on threonine and tyrosine by MKK6. MAPK11 is inhibited by pyridinyl-imidazole related compounds. Highest levels of MAPK11 expression is in the brain and heart. MAPK11 is also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. MAPK11 is dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme. MAPK11 belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family and MAP kinase subfamily. MAPK11 contains 1 protein kinase domain.
Synonyms: PRKM11, SAPK2 (Stress-activated protein kinase 2), p38-2 (Mitogen-activated protein kinase p38 beta), p38b (MAP kinase p38 beta)
|Synonyms||P38B, SAPK2, p38-2, PRKM11, SAPK2B, p38Beta, P38BETA2, P38b, Sapk2, Prkm11, Sapk2b, p38beta, p38beta2, DKFZp586C1322, MAPK11, MGC139500, MGC187942, ATMPK11, F22L4.10, F22L4_10, MAP kinase 11, MPK11, p38b, sapk2, prkm11, sapk2b|
|Restrictions||For Research Use only|
Jiang, Chen, Li et al.: "Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)." in: The Journal of biological chemistry, Vol. 271, Issue 30, pp. 17920-6, 1996 (PubMed).
Kumar, McDonnell, Gum et al.: "Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles." in: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 533-8, 1997 (PubMed).
Stein, Yang, Young et al.: "p38-2, a novel mitogen-activated protein kinase with distinct properties." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19509-17, 1997 (PubMed).
Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).
|Hosts||Rabbit (46), Mouse (6)|
|Reactivities||Human (51), Mouse (Murine) (30), Rat (Rattus) (28), Dog (Canine) (25), Horse (Equine) (19), Cow (Bovine) (6), Cat (Feline) (1), Chicken (1)|
|Applications||Western Blotting (WB) (29), ELISA (26), Immunofluorescence (IF) (23), Immunohistochemistry (IHC) (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (5), N-Term (4), pTyr182,pThr180 (4), AA 251-363 (2), Internal Region (2), AA 39-59 (1), Center (1), pSer93 (1)|