Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
Cross-Reactivity
Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details)
No cross reactivity with other proteins.
Characteristics
Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase 3 (MAPK3) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human MAPK3 , identical to the related mouse and rat sequences.< br/>Immunogen was affinity purified.
Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. MAPK3 gene is mapped to human chromosome 16 by hybrid cell panel analysis.