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Chemokine (C-C Motif) Ligand 2 (CCL2) antibody

Details for Product No. ABIN966545, Supplier: Log in to see
Antigen
  • MCP-1
  • Scya2
  • Sigje
  • GDCF-2
  • HC11
  • HSMCR30
  • MCAF
  • MCP1
  • SCYA2
  • SMC-CF
  • AI323594
  • JE
  • MCP-1A
  • MCP1A
Reactivity
Human
300
100
84
15
11
10
8
7
6
6
4
4
4
1
1
Host
258
140
25
8
8
8
6
Clonality
Monoclonal
Conjugate
Un-conjugated
62
34
21
10
5
3
2
2
2
2
1
1
1
Application
ELISA, Western Blotting (WB)
314
257
85
56
48
44
31
30
29
26
24
22
7
6
5
5
4
3
3
3
3
2
2
1
Supplier
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Isotype IgG1 kappa
Specificity Ni-NTA purified recombinant human MCP-1 expressed in E.Coli strain BL21 (DE3).
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name MCP-1 (CCL2 Antibody Abstract)
Background Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.
Research Area Chemokines
Application Notes Dilution: Western Blot: 1:500-1,000
ELISA: 1,000-2,000.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Yoshimura, Yuhki, Moore et al.: "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE." in: FEBS letters, Vol. 244, Issue 2, pp. 487-93, 1989 (PubMed).

Rollins, Morton, Ledbetter et al.: "Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus." in: Genomics, Vol. 10, Issue 2, pp. 489-92, 1991 (PubMed).

Yoshimura, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1)." in: Advances in experimental medicine and biology, Vol. 305, pp. 47-56, 1992 (PubMed).