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Chemokine (C-C Motif) Ligand 2 (CCL2) antibody

Details for Product No. ABIN966545, Supplier: Log in to see
Antigen
  • AI323594
  • GDCF-2
  • HC11
  • HSMCR30
  • JE
  • MCAF
  • MCP-1
  • MCP-1A
  • MCP1
  • MCP1A
  • SCYA2
  • Scya2
  • Sigje
  • SMC-CF
Reactivity
Human
358
104
99
14
10
9
8
6
6
6
4
4
4
2
1
1
Host
275
179
25
11
9
8
6
Clonality
Monoclonal
Conjugate
Un-conjugated
65
38
23
12
6
6
5
4
4
4
4
4
4
3
3
2
2
2
2
2
1
1
Application
ELISA, Western Blotting (WB)
373
298
96
59
55
49
37
32
31
30
26
22
7
7
6
5
5
4
3
3
3
2
2
1
1
Supplier
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Isotype IgG1 kappa
Specificity Ni-NTA purified recombinant human MCP-1 expressed in E.Coli strain BL21 (DE3).
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name MCP-1 (CCL2 Antibody Abstract)
Background Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.
Research Area Chemokines
Application Notes Dilution: Western Blot: 1:500-1,000
ELISA: 1,000-2,000.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Yoshimura, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1)." in: Advances in experimental medicine and biology, Vol. 305, pp. 47-56, 1992

Rollins, Morton, Ledbetter, Eddy, Shows: "Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus." in: Genomics, Vol. 10, Issue 2, pp. 489-92, 1991

Yoshimura, Yuhki, Moore, Appella, Lerman, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE." in: FEBS letters, Vol. 244, Issue 2, pp. 487-93, 1989