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Chemokine (C-C Motif) Ligand 2 (CCL2) antibody

Details for Product No. ABIN966545, Supplier: Log in to see
Antigen
  • MCP-1
  • Scya2
  • Sigje
  • GDCF-2
  • HC11
  • HSMCR30
  • MCAF
  • MCP1
  • SCYA2
  • SMC-CF
  • AI323594
  • JE
  • MCP-1A
  • MCP1A
  • chemokine (C-C motif) ligand 2
  • macrophage cationic peptide 1
  • mast cell proteinase-1
  • CCL2
  • Ccl2
  • MCP-1
  • MCP1
Alternatives
anti-Human Chemokine (C-C Motif) Ligand 2 antibody for Enzyme Immunoassay
Reactivity
Human
375
127
107
19
14
14
9
8
6
6
4
4
3
2
1
1
Host
272
198
23
14
8
8
4
Clonality
Monoclonal
Conjugate
Un-conjugated
63
35
23
11
7
7
7
6
6
5
5
5
5
4
3
3
3
3
3
2
2
2
Application
ELISA, Western Blotting (WB)
401
306
132
75
64
57
52
51
36
34
31
22
13
6
5
5
4
4
3
2
2
2
2
2
1
1
1
1
Options
Supplier
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Isotype IgG1 kappa
Specificity Ni-NTA purified recombinant human MCP-1 expressed in E.Coli strain BL21 (DE3).
Purification Antibodies are purified by protein A affinity chromatography
Alternative Name MCP-1 (CCL2 Antibody Abstract)
Background Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.
Research Area Chemokines
Pathways Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling
Application Notes Dilution: Western Blot: 1:500-1,000
ELISA: 1,000-2,000.
Restrictions For Research Use only
Storage -20 °C
Product cited in: Yoshimura, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1)." in: Advances in experimental medicine and biology, Vol. 305, pp. 47-56, 1992 (PubMed).

Rollins, Morton, Ledbetter, Eddy, Shows: "Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus." in: Genomics, Vol. 10, Issue 2, pp. 489-92, 1991 (PubMed).

Yoshimura, Yuhki, Moore, Appella, Lerman, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE." in: FEBS letters, Vol. 244, Issue 2, pp. 487-93, 1989 (PubMed).