MERTK antibody

Catalog No. ABIN966566

Product Details anti-MERTK Antibody

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MERTK antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of MER expressed in E. Coli.

Clone: 7E5G1

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-MERTK antibody (ABIN966566)

Allouache, Gawande, Tubiana-Hulin, Tubiana-Mathieu, Piperno-Neumann, Mefti, Bozec, Genot: "First-line therapy with gemcitabine and paclitaxel in locally, recurrent or metastatic breast cancer: a phase II study." in: BMC cancer, Vol. 5, pp. 151, (2005) (PubMed).

Seguineau, Soudant, Moal, Delaporte, Miner, Quéré, Samain: "Techniques for delivery of arachidonic acid to Pacific oyster, Crassostrea gigas, spat." in: Lipids, Vol. 40, Issue 9, pp. 931-9, (2005) (PubMed).

Target Details for MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Alternative Name: MER (MERTK Products)

Synonyms: MER antibody, RP38 antibody, c-mer antibody, Eyk antibody, Mer antibody, Nyk antibody, nmf12 antibody, rdy antibody, C-EYK antibody, MERTK antibody, DKFZp469D2215 antibody, si:ch1073-268l12.2 antibody, MER proto-oncogene, tyrosine kinase antibody, c-mer proto-oncogene tyrosine kinase antibody, c-mer proto-oncogene tyrosine kinase a antibody, MERTK antibody, Mertk antibody, mertka antibody

Background: MER (c-mer proto-oncogene tyrosine kinase) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MER has been identified as a tyrosine kinase potentially involved in the development of glioblastomas. It is expressed at highest levels in ovary, prostate, lung and kidney. Gas6, a growth arrest specific gene, and the related anticoagulation factor Protein S have been identified as ligands for the UFO family of receptors. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Synonyms: MER, RP38, c-mer, MGC133349, MERTK

Gene ID: 10461

Pathways: RTK Signaling