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Neurofibromin 2 (NF2) (pSer518) antibody

Details for Product No. ABIN966567, Supplier: Log in to see
Antigen
  • ACN
  • BANF
  • merlin
  • nf2
  • NF2
  • NF2a
  • SCH
  • zgc:194620
  • zgc:194631
Epitope
pSer518
52
14
13
12
9
8
7
5
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
143
92
75
13
5
5
1
1
1
Host
Rabbit
137
18
7
Conjugate
Un-conjugated
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (IHC)
108
66
41
34
22
21
11
8
6
2
1
Supplier
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Merlin around the phosphorylation site of serine 518 (R-L-SP-M-E).
Specificity Merlin (phospho-Ser518) antibody detects endogenous levels of Merlin only when phosphorylated at serine 518.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Alternative Name Merlin (NF2 Antibody Abstract)
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Xiao, Gallagher, Shetler, Skele, Altomare, Pestell, Jhanwar, Testa: "The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression." in: Molecular and cellular biology, Vol. 25, Issue 6, pp. 2384-94, 2005

Ratner, Bryan, Weber, Nguyen, Barnes, Pitt, Gelber, Cheung, Prince: "Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19267-75, 2001

Böhni, Hemmi, Aguet: "Signaling steps involving the cytoplasmic domain of the interferon-gamma receptor alpha-subunit are not species-specific." in: The Journal of biological chemistry, Vol. 269, Issue 20, pp. 14541-5, 1994